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MAPK4 mitogen-activated protein kinase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 491690, updated on 5-Mar-2024

Summary

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Official Symbol
MAPK4provided by VGNC
Official Full Name
mitogen-activated protein kinase 4provided by VGNC
Primary source
VGNC:VGNC:42998
See related
Ensembl:ENSCAFG00845017990
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (80742157..80890788)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (80065812..80213476)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (80773177..80921788)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (80455019..80602388)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (80485405..80633823)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore associated complex subunit 1 Neighboring gene uncharacterized LOC111096923 Neighboring gene uncharacterized LOC111096845 Neighboring gene uncharacterized LOC119872631 Neighboring gene uncharacterized LOC119872632 Neighboring gene protein maestro-like Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 4
XP_013971088.1
XP_022277382.1
XP_038338480.1
XP_038338481.1
XP_038338482.1
XP_038338483.1
XP_038338484.1
XP_038399934.1
XP_038399935.1
XP_038399936.1
XP_038399937.1
XP_038399938.1
XP_038435248.1
XP_038435253.1
XP_038435257.1
XP_038464042.1
XP_038464043.1
XP_038464044.1
XP_038464045.1
XP_038464046.1
XP_038528750.1
XP_038528751.1
XP_038528752.1
XP_038528753.1
XP_038528754.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    80742157..80890788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672822.1 → XP_038528750.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Related
    ENSCAFP00845024979.1, ENSCAFT00845031944.1
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  2. XM_038672823.1 → XP_038528751.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Related
    ENSCAFP00845024918.1, ENSCAFT00845031847.1
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  3. XM_038672825.1 → XP_038528753.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  4. XM_038672824.1 → XP_038528752.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  5. XM_038672826.1 → XP_038528754.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (2) summary
    PRK07764
    Location:252 → 322
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl21453
    Location:1 → 140
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    80455019..80602388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038482552.1 → XP_038338480.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  2. XM_038482553.1 → XP_038338481.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  3. XM_038482555.1 → XP_038338483.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  4. XM_038482554.1 → XP_038338482.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  5. XM_038482556.1 → XP_038338484.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (2) summary
    PRK07764
    Location:252 → 322
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl21453
    Location:1 → 140
    PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    80485405..80633823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038608114.1 → XP_038464042.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  2. XM_038608115.1 → XP_038464043.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  3. XM_038608117.1 → XP_038464045.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  4. XM_038608116.1 → XP_038464044.1  mitogen-activated protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  5. XM_038608118.1 → XP_038464046.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (2) summary
    PRK07764
    Location:252 → 322
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl21453
    Location:1 → 140
    PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    80773177..80921788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544006.1 → XP_038399934.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  2. XM_038544007.1 → XP_038399935.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  3. XM_038544009.1 → XP_038399937.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  4. XM_038544008.1 → XP_038399936.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  5. XM_038544010.1 → XP_038399938.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (2) summary
    PRK07764
    Location:252 → 322
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl21453
    Location:1 → 140
    PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    80065812..80213476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038579320.1 → XP_038435248.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  2. XM_038579325.1 → XP_038435253.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  3. XM_022421674.2 → XP_022277382.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  4. XM_038579329.1 → XP_038435257.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLN5, A0A8C0LYV1, A0A8C0SRW0, A0A8I3NVA1, A0A8I3P551
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  5. XM_014115613.3 → XP_013971088.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (2) summary
    PRK07764
    Location:252 → 322
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl21453
    Location:1 → 140
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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