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ALAS2 5'-aminolevulinate synthase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 491498, updated on 5-Mar-2024

Summary

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Official Symbol
ALAS2provided by VGNC
Official Full Name
5'-aminolevulinate synthase 2provided by VGNC
Primary source
VGNC:VGNC:37777
See related
Ensembl:ENSCAFG00845030308
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (46992131..47018312, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (38039113..38065286, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (46910743..46936916, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (46501907..46528079, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (46968475..46994644, complement)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Neighboring gene small EDRK-rich factor 2-like Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2 Neighboring gene probable G-protein coupled receptor 160 Neighboring gene VCP nuclear cofactor family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A PCR-RFLP marker for the erythroid aminolevulinate synthase gene (ALAS2) on canine chromosome X. Boyer G, et al. Anim Genet, 1995 Jun. PMID 7793698

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5-aminolevulinate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Names
aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)
erythroid aminolevulinate synthase
XP_038306048.1
XP_038306049.1
XP_038320456.1
XP_038320457.1
XP_038379502.1
XP_038379503.1
XP_038443461.1
XP_038443462.1
XP_038507988.1
XP_038507989.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    46992131..47018312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038450120.1 → XP_038306048.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    UniProtKB/TrEMBL
    A0A8C0KM77, A0A8C0TMN6, A0A8C0Z4Z9, A0A8I3QB56, A0A8I3QXP6
    Related
    ENSCAFP00845042272.1, ENSCAFT00845053787.1
    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

  2. XM_038450121.1 → XP_038306049.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    UniProtKB/TrEMBL
    A0A8C0KM77, A0A8C0TMN6, A0A8C0Z4Z9, A0A8I3QB56, A0A8I3QXP6
    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    46501907..46528079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038523574.1 → XP_038379502.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

  2. XM_038523575.1 → XP_038379503.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    46968475..46994644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038652060.1 → XP_038507988.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

  2. XM_038652061.1 → XP_038507989.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    46910743..46936916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038587533.1 → XP_038443461.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    UniProtKB/TrEMBL
    A0A8C0KM77, A0A8C0TMN6, A0A8C0Z4Z9, A0A8I3QB56, A0A8I3QXP6
    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

  2. XM_038587534.1 → XP_038443462.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    UniProtKB/TrEMBL
    A0A8C0KM77, A0A8C0TMN6, A0A8C0Z4Z9, A0A8I3QB56, A0A8I3QXP6
    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38039113..38065286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464528.1 → XP_038320456.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    UniProtKB/TrEMBL
    A0A8C0KM77, A0A8C0TMN6, A0A8C0Z4Z9, A0A8I3QB56, A0A8I3QXP6
    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence

  2. XM_038464529.1 → XP_038320457.1  5-aminolevulinate synthase, erythroid-specific, mitochondrial

    UniProtKB/TrEMBL
    A0A8C0KM77, A0A8C0TMN6, A0A8C0Z4Z9, A0A8I3QB56, A0A8I3QXP6
    Conserved Domains (2) summary
    TIGR01821
    Location:143 → 548
    5aminolev_synth; 5-aminolevulinic acid synthase
    pfam09029
    Location:5 → 100
    Preseq_ALAS; 5-aminolevulinate synthase presequence
Nucleotide Protein
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