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SH2D3C SH2 domain containing 3C [ Canis lupus familiaris (dog) ]

Gene ID: 491326, updated on 5-Mar-2024

Summary

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Official Symbol
SH2D3Cprovided by VGNC
Official Full Name
SH2 domain containing 3Cprovided by VGNC
Primary source
VGNC:VGNC:46113
See related
Ensembl:ENSCAFG00845005416
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (56547903..56578173)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (54819942..54850176)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (55714308..55744373)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (55308165..55338424)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (55622873..55653134)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene COX assembly mitochondrial protein 2 homolog Neighboring gene cyclin dependent kinase 9 Neighboring gene torsin family 2 member A Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene cilia and flagella associated protein 157 Neighboring gene peptidyl-tRNA hydrolase 1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH2 domain-containing protein 3C

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    56547903..56578173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678509.1 → XP_038534437.1  SH2 domain-containing protein 3C isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z0E3, A0A8I3MR13
    Related
    ENSCAFP00845007575.1, ENSCAFT00845009689.1
    Conserved Domains (2) summary
    cd10337
    Location:211 → 345
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:584 → 761
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_038678511.1 → XP_038534439.1  SH2 domain-containing protein 3C isoform X3

    UniProtKB/TrEMBL
    A0A8C0R1Q3, A0A8C0SXP1, A0A8I3MX00
    Related
    ENSCAFP00845007584.1, ENSCAFT00845009700.1
    Conserved Domains (2) summary
    cd10337
    Location:56 → 190
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:429 → 606
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_038678510.1 → XP_038534438.1  SH2 domain-containing protein 3C isoform X2

    UniProtKB/TrEMBL
    A0A8I3MVN7, A0A8P0TVI0
    Related
    ENSCAFP00845007561.1, ENSCAFT00845009675.1
    Conserved Domains (2) summary
    cd10337
    Location:58 → 192
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:431 → 608
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_038678512.1 → XP_038534440.1  SH2 domain-containing protein 3C isoform X4

    UniProtKB/TrEMBL
    A0A8C0N6J2, A0A8I3MTI8
    Related
    ENSCAFP00845007609.1, ENSCAFT00845009730.1
    Conserved Domains (2) summary
    cd10337
    Location:55 → 189
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:428 → 605
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    55308165..55338424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487349.1 → XP_038343277.1  SH2 domain-containing protein 3C isoform X1

    Conserved Domains (2) summary
    cd10337
    Location:211 → 345
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:584 → 761
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_038487351.1 → XP_038343279.1  SH2 domain-containing protein 3C isoform X3

    Conserved Domains (2) summary
    cd10337
    Location:56 → 190
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:429 → 606
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_038487350.1 → XP_038343278.1  SH2 domain-containing protein 3C isoform X2

    Conserved Domains (2) summary
    cd10337
    Location:58 → 192
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:431 → 608
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_038487352.1 → XP_038343280.1  SH2 domain-containing protein 3C isoform X4

    Conserved Domains (2) summary
    cd10337
    Location:55 → 189
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:428 → 605
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    55622873..55653134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613221.1 → XP_038469149.1  SH2 domain-containing protein 3C isoform X1

  2. XM_038613223.1 → XP_038469151.1  SH2 domain-containing protein 3C isoform X3

    Conserved Domains (2) summary
    cd10337
    Location:56 → 190
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:429 → 606
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_038613222.1 → XP_038469150.1  SH2 domain-containing protein 3C isoform X2

    Conserved Domains (2) summary
    cd10337
    Location:58 → 192
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:431 → 608
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_038613224.1 → XP_038469152.1  SH2 domain-containing protein 3C isoform X4

    Conserved Domains (2) summary
    cd10337
    Location:55 → 189
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:428 → 605
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    55714308..55744373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549278.1 → XP_038405206.1  SH2 domain-containing protein 3C isoform X1

    UniProtKB/TrEMBL
    A0A8C0MWH8

  2. XM_038549280.1 → XP_038405208.1  SH2 domain-containing protein 3C isoform X3

    UniProtKB/TrEMBL
    A0A8C0R1Q3, A0A8C0SXP1, A0A8I3MX00
    Conserved Domains (2) summary
    cd10337
    Location:56 → 190
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:429 → 606
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_038549279.1 → XP_038405207.1  SH2 domain-containing protein 3C isoform X2

    UniProtKB/TrEMBL
    A0A8I3MVN7, A0A8P0TVI0
    Conserved Domains (2) summary
    cd10337
    Location:58 → 192
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:431 → 608
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_038549281.1 → XP_038405209.1  SH2 domain-containing protein 3C isoform X4

    UniProtKB/TrEMBL
    A0A8C0N6J2, A0A8I3MTI8
    Conserved Domains (2) summary
    cd10337
    Location:55 → 189
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:428 → 605
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    54819942..54850176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_548447.5 → XP_548447.2  SH2 domain-containing protein 3C isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z0E3, A0A8I3MR13
    Conserved Domains (2) summary
    cd10337
    Location:211 → 345
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:584 → 761
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_857580.6 → XP_862673.2  SH2 domain-containing protein 3C isoform X3

    UniProtKB/TrEMBL
    A0A8C0R1Q3, A0A8C0SXP1, A0A8I3MX00
    Conserved Domains (2) summary
    cd10337
    Location:56 → 190
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:429 → 606
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_005625333.3 → XP_005625390.1  SH2 domain-containing protein 3C isoform X2

    UniProtKB/TrEMBL
    A0A8I3MVN7, A0A8P0TVI0
    Conserved Domains (2) summary
    cd10337
    Location:58 → 192
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:431 → 608
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_857608.6 → XP_862701.1  SH2 domain-containing protein 3C isoform X4

    UniProtKB/TrEMBL
    A0A8C0N6J2, A0A8I3MTI8
    Conserved Domains (2) summary
    cd10337
    Location:55 → 189
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:428 → 605
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
Nucleotide Protein
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