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ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 491292, updated on 5-Mar-2024

Summary

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Official Symbol
ABL1provided by VGNC
Official Full Name
ABL proto-oncogene 1, non-receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:54912
See related
Ensembl:ENSCAFG00845020595
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (54019016..54162127, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (52318603..52461396, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (53210098..53353656, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (52796621..52939392, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (53117155..53260443, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene fibrinogen C domain containing 1 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene uncharacterized LOC119873357 Neighboring gene exosome component 2 Neighboring gene PR/SET domain 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase ABL1
Names
c-abl oncogene 1, non-receptor tyrosine kinase
c-abl oncogene 1, receptor tyrosine kinase
v-abl Abelson murine leukemia viral oncogene homolog 1
XP_005625289.1
XP_038343059.1
XP_038343060.1
XP_038404947.1
XP_038404948.1
XP_038468898.1
XP_038468899.1
XP_038534204.1
XP_038534205.1
XP_548413.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    54019016..54162127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678276.1 → XP_038534204.1  tyrosine-protein kinase ABL1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N5E8, A0A8C0RIB7, A0A8I3PAE8, A0A8I3S4H5
    Related
    ENSCAFP00845028399.1, ENSCAFT00845036288.1
    Conserved Domains (4) summary
    smart00808
    Location:1026 → 1150
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:142 → 235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84 → 137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:254 → 516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

  2. XM_038678277.1 → XP_038534205.1  tyrosine-protein kinase ABL1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QAE1, A0A8C0R6W7, A0A8I3P8R8
    Related
    ENSCAFP00845028588.1, ENSCAFT00845036533.1
    Conserved Domains (4) summary
    smart00808
    Location:1007 → 1131
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:123 → 216
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:65 → 118
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:235 → 497
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    52796621..52939392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487131.1 → XP_038343059.1  tyrosine-protein kinase ABL1 isoform X1

    Conserved Domains (4) summary
    smart00808
    Location:1026 → 1150
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:142 → 235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84 → 137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:254 → 516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

  2. XM_038487132.1 → XP_038343060.1  tyrosine-protein kinase ABL1 isoform X2

    Conserved Domains (4) summary
    smart00808
    Location:1007 → 1131
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:123 → 216
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:65 → 118
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:235 → 497
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    53117155..53260443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612970.1 → XP_038468898.1  tyrosine-protein kinase ABL1 isoform X1

    Conserved Domains (4) summary
    smart00808
    Location:1026 → 1150
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:142 → 235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84 → 137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:254 → 516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

  2. XM_038612971.1 → XP_038468899.1  tyrosine-protein kinase ABL1 isoform X2

    Conserved Domains (4) summary
    smart00808
    Location:1007 → 1131
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:123 → 216
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:65 → 118
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:235 → 497
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    53210098..53353656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549019.1 → XP_038404947.1  tyrosine-protein kinase ABL1 isoform X1

    UniProtKB/TrEMBL
    A0A8P0NXV5, A0A8P0SPC2

  2. XM_038549020.1 → XP_038404948.1  tyrosine-protein kinase ABL1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R6W7, A0A8P0SNT5

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    52318603..52461396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_548413.7 → XP_548413.3  tyrosine-protein kinase ABL1 isoform X1

    UniProtKB/TrEMBL
    A0A8P0NXV5, A0A8P0SPC2
    Conserved Domains (5) summary
    smart00808
    Location:1026 → 1150
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:142 → 235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84 → 137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:254 → 516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:261 → 512
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_005625232.3 → XP_005625289.1  tyrosine-protein kinase ABL1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0R6W7, A0A8P0SNT5
    Conserved Domains (5) summary
    smart00808
    Location:1007 → 1131
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:123 → 216
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:65 → 118
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:235 → 497
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:242 → 493
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
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