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RXRA retinoid X receptor alpha [ Canis lupus familiaris (dog) ]

Gene ID: 491278, updated on 5-Mar-2024

Summary

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Official Symbol
RXRAprovided by VGNC
Official Full Name
retinoid X receptor alphaprovided by VGNC
Primary source
VGNC:VGNC:45817
See related
Ensembl:ENSCAFG00845012191
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
RXRalpha
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (51360100..51453773)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (49766609..49860130)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (50541613..50635257)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (50120766..50214385)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (50464001..50557538)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119873349 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene WD repeat domain 5 Neighboring gene uncharacterized LOC111097475 Neighboring gene collagen type V alpha 1 chain Neighboring gene cell division protein ZipA-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear receptor and target gene mRNA abundance in duodenum and colon of dogs with chronic enteropathies. Greger DL, et al. Domest Anim Endocrinol, 2006 Nov. PMID 16446074
  2. Nuclear receptor and nuclear receptor target gene messenger ribonucleic acid levels at different sites of the gastrointestinal tract and in liver of healthy dogs. Gropp FN, et al. J Anim Sci, 2006 Oct. PMID 16971569
  3. Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Waxman JS, et al. Dev Dyn, 2007 Feb. PMID 17195188

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables retinoic acid-responsive element binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinoic acid receptor RXR-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    51360100..51453773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678108.1 → XP_038534036.1  retinoic acid receptor RXR-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0LJL8, A0A8C0PE67, A0A8C0Q3S5, A0A8I3NNU7, A0A8I3RWY2
    Related
    ENSCAFP00845017042.1, ENSCAFT00845021676.1
    Conserved Domains (3) summary
    cd06943
    Location:234 → 445
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:138 → 214
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:18 → 131
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

  2. XM_038678107.1 → XP_038534035.1  retinoic acid receptor RXR-alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Q3S5, A0A8I3NNU7, A0A8P0NVU1
    Related
    ENSCAFP00845017352.1, ENSCAFT00845022069.1
    Conserved Domains (3) summary
    cd06943
    Location:206 → 417
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:110 → 186
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:1 → 103
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    50120766..50214385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487010.1 → XP_038342938.1  retinoic acid receptor RXR-alpha isoform X2

    Conserved Domains (3) summary
    cd06943
    Location:234 → 445
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:138 → 214
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:18 → 131
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

  2. XM_038487009.1 → XP_038342937.1  retinoic acid receptor RXR-alpha isoform X1

    Conserved Domains (3) summary
    cd06943
    Location:206 → 417
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:110 → 186
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:1 → 103
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    50464001..50557538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612810.1 → XP_038468738.1  retinoic acid receptor RXR-alpha isoform X2

    Conserved Domains (3) summary
    cd06943
    Location:234 → 445
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:138 → 214
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:18 → 131
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

  2. XM_038612808.1 → XP_038468736.1  retinoic acid receptor RXR-alpha isoform X1

    Conserved Domains (3) summary
    cd06943
    Location:206 → 417
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:110 → 186
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:1 → 103
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    50541613..50635257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548860.1 → XP_038404788.1  retinoic acid receptor RXR-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0LJL8, A0A8C0PE67, A0A8C0Q3S5, A0A8I3NNU7, A0A8I3RWY2
    Conserved Domains (3) summary
    cd06943
    Location:234 → 445
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:138 → 214
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:18 → 131
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

  2. XM_038548859.1 → XP_038404787.1  retinoic acid receptor RXR-alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Q3S5, A0A8I3NNU7, A0A8P0NVU1
    Conserved Domains (3) summary
    cd06943
    Location:206 → 417
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:110 → 186
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:1 → 103
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49766609..49860130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038615598.1 → XP_038471526.1  retinoic acid receptor RXR-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0LJL8, A0A8C0PE67, A0A8C0Q3S5, A0A8I3NNU7, A0A8I3RWY2
    Conserved Domains (3) summary
    cd06943
    Location:234 → 445
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:138 → 214
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:18 → 131
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

  2. XM_005625159.4 → XP_005625216.2  retinoic acid receptor RXR-alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0Q3S5, A0A8I3NNU7, A0A8P0NVU1
    Conserved Domains (3) summary
    cd06943
    Location:206 → 417
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:110 → 186
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:1 → 103
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
Nucleotide Protein
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