U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MMP28 matrix metallopeptidase 28 [ Canis lupus familiaris (dog) ]

Gene ID: 491136, updated on 5-Mar-2024

Summary

Official Symbol
MMP28provided by VGNC
Official Full Name
matrix metallopeptidase 28provided by VGNC
Primary source
VGNC:VGNC:43287
See related
Ensembl:ENSCAFG00845009411
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (38685116..38719456)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (37097600..37131941)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (37840856..37875211)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (37467864..37502250)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (37753363..37787721)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097421 Neighboring gene HEAT repeat containing 9 Neighboring gene TATA-box binding protein associated factor 15 Neighboring gene uncharacterized LOC111097422 Neighboring gene chromosome 9 C17orf50 homolog Neighboring gene uncharacterized LOC119873316 Neighboring gene growth arrest specific 2 like 2

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
matrix metalloproteinase-28

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    38685116..38719456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038677300.1XP_038533228.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  2. XM_038677299.1XP_038533227.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  3. XM_038677297.1XP_038533225.1  matrix metalloproteinase-28 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUA4, A0A8C0QB99, A0A8I3NDY2
    Related
    ENSCAFP00845012900.1, ENSCAFT00845016584.1
    Conserved Domains (3) summary
    cd00094
    Location:321510
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
  4. XM_038677298.1XP_038533226.1  matrix metalloproteinase-28 isoform X2

    Conserved Domains (3) summary
    cd00094
    Location:239428
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl00064
    Location:129202
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  5. XM_038677301.1XP_038533229.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    37467864..37502250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486263.1XP_038342191.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  2. XM_038486262.1XP_038342190.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  3. XM_038486260.1XP_038342188.1  matrix metalloproteinase-28 isoform X1

    Conserved Domains (3) summary
    cd00094
    Location:321510
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
  4. XM_038486261.1XP_038342189.1  matrix metalloproteinase-28 isoform X2

    Conserved Domains (3) summary
    cd00094
    Location:239428
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl00064
    Location:129202
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  5. XM_038486264.1XP_038342192.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    37753363..37787721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612052.1XP_038467980.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  2. XM_038612051.1XP_038467979.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  3. XM_038612049.1XP_038467977.1  matrix metalloproteinase-28 isoform X1

    Conserved Domains (3) summary
    cd00094
    Location:321510
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
  4. XM_038612050.1XP_038467978.1  matrix metalloproteinase-28 isoform X2

    Conserved Domains (3) summary
    cd00094
    Location:239428
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl00064
    Location:129202
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  5. XM_038612053.1XP_038467981.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    37840856..37875211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548082.1XP_038404010.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  2. XM_038548081.1XP_038404009.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  3. XM_038548079.1XP_038404007.1  matrix metalloproteinase-28 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUA4, A0A8C0QB99, A0A8I3NDY2
    Conserved Domains (3) summary
    cd00094
    Location:321510
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
  4. XM_038548080.1XP_038404008.1  matrix metalloproteinase-28 isoform X2

    Conserved Domains (3) summary
    cd00094
    Location:239428
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl00064
    Location:129202
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  5. XM_038548083.1XP_038404011.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37097600..37131941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022423300.2XP_022279008.2  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  2. XM_022423299.2XP_022279007.2  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  3. XM_548256.7XP_548256.3  matrix metalloproteinase-28 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUA4, A0A8C0QB99, A0A8I3NDY2
    Conserved Domains (3) summary
    cd00094
    Location:321510
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
  4. XM_038609254.1XP_038465182.1  matrix metalloproteinase-28 isoform X2

    Conserved Domains (3) summary
    cd00094
    Location:239428
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl00064
    Location:129202
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  5. XM_038609272.1XP_038465200.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...