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ABCC3 ATP binding cassette subfamily C member 3 [ Canis lupus familiaris (dog) ]

Gene ID: 491084, updated on 5-Mar-2024

Summary

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Official Symbol
ABCC3provided by VGNC
Official Full Name
ATP binding cassette subfamily C member 3provided by VGNC
Primary source
VGNC:VGNC:49912
See related
Ensembl:ENSCAFG00845014515
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (27346054..27390624)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (25944553..25988893)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (26502563..26547109)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (26113720..26158047)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (26372406..26416803)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 20 Neighboring gene calcium voltage-gated channel subunit alpha1 G Neighboring gene uncharacterized LOC111097377 Neighboring gene ankyrin repeat domain 40 Neighboring gene uncharacterized LOC111097378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells. Pawłowski KM, et al. BMC Vet Res, 2013 Jun 17. PMID 23773525, Free PMC Article
  2. ABC transporters in the eyes of dogs and implications in drug therapy. Haritova AM, et al. Curr Eye Res, 2013 Feb. PMID 23373631
  3. Nuclear receptor and target gene mRNA abundance in duodenum and colon of dogs with chronic enteropathies. Greger DL, et al. Domest Anim Endocrinol, 2006 Nov. PMID 16446074
  4. Nuclear receptor and nuclear receptor target gene messenger ribonucleic acid levels at different sites of the gastrointestinal tract and in liver of healthy dogs. Gropp FN, et al. J Anim Sci, 2006 Oct. PMID 16971569

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRP3 - expression and role in multidrug resistance of mammary cancer cells
    Title: Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells.
  2. ABCC1, ABCC3 and ABCC4 are expressed predominantly in the conjunctiva and at very low levels in the cornea.
    Title: ABC transporters in the eyes of dogs and implications in drug therapy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
canalicular multispecific organic anion transporter 2
Names
multidrug resistance protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    27346054..27390624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676884.1 → XP_038532812.1  canalicular multispecific organic anion transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3RY64, A0A8I3S0X8
    Related
    ENSCAFP00845020480.1, ENSCAFT00845025981.1
    Conserved Domains (1) summary
    TIGR00957
    Location:6 → 1522
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  2. XM_038676885.1 → XP_038532813.1  canalicular multispecific organic anion transporter 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3RY64
    Conserved Domains (1) summary
    TIGR00957
    Location:1 → 1302
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    26113720..26158047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485900.1 → XP_038341828.1  canalicular multispecific organic anion transporter 2 isoform X1

  2. XM_038485901.1 → XP_038341829.1  canalicular multispecific organic anion transporter 2 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    26372406..26416803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611659.1 → XP_038467587.1  canalicular multispecific organic anion transporter 2 isoform X1

  2. XM_038611660.1 → XP_038467588.1  canalicular multispecific organic anion transporter 2 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    26502563..26547109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547687.1 → XP_038403615.1  canalicular multispecific organic anion transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NRM3, A0A8C0TW46, A0A8P0SLR2, A0A8P0SST7

  2. XM_038547688.1 → XP_038403616.1  canalicular multispecific organic anion transporter 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TW46, A0A8P0SST7

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25944553..25988893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005624674.4 → XP_005624731.1  canalicular multispecific organic anion transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NRM3, A0A8C0TW46, A0A8P0SLR2, A0A8P0SST7
    Conserved Domains (4) summary
    TIGR00957
    Location:6 → 1522
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1283 → 1503
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:622 → 823
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:977 → 1236
    ABC_membrane; ABC transporter transmembrane region

  2. XM_022423112.2 → XP_022278820.1  canalicular multispecific organic anion transporter 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TW46, A0A8P0SST7
    Conserved Domains (1) summary
    cl26602
    Location:1 → 1302
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
Nucleotide Protein
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