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STAT5B signal transducer and activator of transcription 5B [ Canis lupus familiaris (dog) ]

Gene ID: 490969, updated on 11-Apr-2024

Summary

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Official Symbol
STAT5Bprovided by VGNC
Official Full Name
signal transducer and activator of transcription 5Bprovided by VGNC
Primary source
VGNC:VGNC:55825
See related
Ensembl:ENSCAFG00845009970
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Genomic context

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Location:
chromosome: 9
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (21367403..21437279)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (20109403..20179537)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (20522505..20592735)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (20152431..20222600)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (20419706..20489689)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 5A Neighboring gene uncharacterized LOC119873266 Neighboring gene proline-rich protein HaeIII subfamily 1-like Neighboring gene GH3 domain containing Neighboring gene hypocretin neuropeptide precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of DNA markers informative in purebred dog families by genomic representational difference analysis (gRDA). Everts RE, et al. Mamm Genome, 2000 Sep. PMID 10967132

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    21367403..21437279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676451.1 → XP_038532379.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHJ2, A0A8C0S0Y3, A0A8I3N974, A0A8I3RXG9
    Related
    ENSCAFP00845013723.1, ENSCAFT00845017626.1
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. XM_038676453.1 → XP_038532381.1  signal transducer and activator of transcription 5B isoform X2

    UniProtKB/TrEMBL
    A0A8C0LWA6
    Related
    ENSCAFP00845013643.1, ENSCAFT00845017531.1
    Conserved Domains (4) summary
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cl15255
    Location:573 → 693
    SH2; Src homology 2 (SH2) domain

  3. XM_038676452.1 → XP_038532380.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHJ2, A0A8C0S0Y3, A0A8I3N974, A0A8I3RXG9
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  4. XM_038676454.1 → XP_038532382.1  signal transducer and activator of transcription 5B isoform X3

    UniProtKB/TrEMBL
    A0A8I3N974
    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

  5. XM_038676455.1 → XP_038532383.1  signal transducer and activator of transcription 5B isoform X3

    UniProtKB/TrEMBL
    A0A8I3N974
    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    20152431..20222600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485528.1 → XP_038341456.1  signal transducer and activator of transcription 5B isoform X1

    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. XM_038485529.1 → XP_038341457.1  signal transducer and activator of transcription 5B isoform X2

    Conserved Domains (4) summary
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cl15255
    Location:573 → 693
    SH2; Src homology 2 (SH2) domain

  3. XM_038485527.1 → XP_038341455.1  signal transducer and activator of transcription 5B isoform X1

    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  4. XM_038485530.1 → XP_038341458.1  signal transducer and activator of transcription 5B isoform X3

    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

  5. XM_038485531.1 → XP_038341459.1  signal transducer and activator of transcription 5B isoform X3

    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    20419706..20489689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611261.1 → XP_038467189.1  signal transducer and activator of transcription 5B isoform X1

    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. XM_038611263.1 → XP_038467191.1  signal transducer and activator of transcription 5B isoform X2

    Conserved Domains (4) summary
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cl15255
    Location:573 → 693
    SH2; Src homology 2 (SH2) domain

  3. XM_038611262.1 → XP_038467190.1  signal transducer and activator of transcription 5B isoform X1

    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  4. XM_038611264.1 → XP_038467192.1  signal transducer and activator of transcription 5B isoform X3

    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

  5. XM_038611265.1 → XP_038467193.1  signal transducer and activator of transcription 5B isoform X3

    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    20522505..20592735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547294.1 → XP_038403222.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHJ2, A0A8C0S0Y3, A0A8I3N974, A0A8I3RXG9
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. XM_038547295.1 → XP_038403223.1  signal transducer and activator of transcription 5B isoform X2

    UniProtKB/TrEMBL
    A0A8C0LWA6
    Conserved Domains (4) summary
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cl15255
    Location:573 → 693
    SH2; Src homology 2 (SH2) domain

  3. XM_038547293.1 → XP_038403221.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHJ2, A0A8C0S0Y3, A0A8I3N974, A0A8I3RXG9
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  4. XM_038547296.1 → XP_038403224.1  signal transducer and activator of transcription 5B isoform X3

    UniProtKB/TrEMBL
    A0A8I3N974
    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

  5. XM_038547297.1 → XP_038403225.1  signal transducer and activator of transcription 5B isoform X3

    UniProtKB/TrEMBL
    A0A8I3N974
    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    20109403..20179537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038602762.1 → XP_038458690.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHJ2, A0A8C0S0Y3, A0A8I3N974, A0A8I3RXG9
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. XM_005624461.4 → XP_005624518.1  signal transducer and activator of transcription 5B isoform X2

    UniProtKB/TrEMBL
    A0A8C0LWA6
    Conserved Domains (4) summary
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cl15255
    Location:573 → 693
    SH2; Src homology 2 (SH2) domain

  3. XM_548092.7 → XP_548092.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHJ2, A0A8C0S0Y3, A0A8I3N974, A0A8I3RXG9
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  4. XM_005624462.3 → XP_005624519.1  signal transducer and activator of transcription 5B isoform X3

    See identical proteins and their annotated locations for XP_005624519.1

    UniProtKB/TrEMBL
    A0A8I3N974
    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain

  5. XM_038602790.1 → XP_038458718.1  signal transducer and activator of transcription 5B isoform X3

    UniProtKB/TrEMBL
    A0A8I3N974
    Conserved Domains (4) summary
    cd10420
    Location:471 → 615
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:37 → 228
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:230 → 387
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cl03749
    Location:1 → 22
    STAT_int; STAT protein, protein interaction domain
Nucleotide Protein
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