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STAT3 signal transducer and activator of transcription 3 [ Canis lupus familiaris (dog) ]

Gene ID: 490967, updated on 11-Apr-2024

Summary

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Official Symbol
STAT3provided by VGNC
Official Full Name
signal transducer and activator of transcription 3provided by VGNC
Primary source
VGNC:VGNC:46890
See related
Ensembl:ENSCAFG00845009322
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (21258611..21334353)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (20001678..20076249)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (20413942..20489100)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (20044250..20119519)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (20309625..20386466)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit a1 Neighboring gene caveolae associated protein 1 Neighboring gene signal transducer and activator of transcription 5A Neighboring gene uncharacterized LOC119873266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immunodetection of the signal transducer and activator of transcription-3 in canine haemangioma and haemangiosarcoma. Petterino C, et al. Res Vet Sci, 2006 Apr. PMID 16098550
  2. Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma. Liu IL, et al. Vet Comp Oncol, 2021 Mar. PMID 32720434
  3. Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer? Lin HY, et al. J Comp Pathol, 2016 Aug-Oct. PMID 27401955
  4. Characterization of STAT3 activation and expression in canine and human osteosarcoma. Fossey SL, et al. BMC Cancer, 2009 Mar 10. PMID 19284568, Free PMC Article
  5. Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase. Park SM, et al. PLoS One, 2021. PMID 34310627, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase.
    Title: Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase.
  2. Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
    Title: Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
  3. Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma.
    Title: Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma.
  4. The data suggest that overexpression of STAT3 and downregulation of PTEN may be an important step in canine prostate carcinogenesis
    Title: Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer?
  5. Tumor-infiltrating myeloid precursor cells may invigorate STAT3 activity (probably via vascular endothelial growth factor) that contributes to tumor angiogenesis & ability to metastasize. Semaphorin 3B & neuropilin receptors may also be important.
    Title: Density of Gr1-positive myeloid precursor cells, p-STAT3 expression and gene expression pattern in canine mammary cancer metastasis.
  6. Data suggest that STAT3 activation contributes to the survival and proliferation of OSA cells, thereby providing a potentially promising target for therapeutic intervention.
    Title: Characterization of STAT3 activation and expression in canine and human osteosarcoma.
  7. Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation.
    Title: Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation.
  8. The expression of signal transducer and activator of transcription 3 (STAT3) in canine haemangiomas and haemangiosarcomas is reported.
    Title: Immunodetection of the signal transducer and activator of transcription-3 in canine haemangioma and haemangiosarcoma.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leptin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    21258611..21334353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676446.1 → XP_038532374.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Related
    ENSCAFP00845012818.1, ENSCAFT00845016484.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  2. XM_038676447.1 → XP_038532375.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  3. XM_038676442.1 → XP_038532370.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Related
    ENSCAFP00845012909.1, ENSCAFT00845016596.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  4. XM_038676444.1 → XP_038532372.1  signal transducer and activator of transcription 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I3N7F2, A0A8P0P0B7
    Related
    ENSCAFP00845013161.1, ENSCAFT00845016907.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  5. XM_038676443.1 → XP_038532371.1  signal transducer and activator of transcription 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N7S6
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  6. XM_038676445.1 → XP_038532373.1  signal transducer and activator of transcription 3 isoform X4

    UniProtKB/TrEMBL
    A0A8I3N7F2, A0A8P0P0B7
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    20044250..20119519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485524.1 → XP_038341452.1  signal transducer and activator of transcription 3 isoform X1

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  2. XM_038485525.1 → XP_038341453.1  signal transducer and activator of transcription 3 isoform X1

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  3. XM_038485520.1 → XP_038341448.1  signal transducer and activator of transcription 3 isoform X1

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  4. XM_038485522.1 → XP_038341450.1  signal transducer and activator of transcription 3 isoform X3

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  5. XM_038485521.1 → XP_038341449.1  signal transducer and activator of transcription 3 isoform X2

    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  6. XM_038485523.1 → XP_038341451.1  signal transducer and activator of transcription 3 isoform X4

    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    20309625..20386466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611258.1 → XP_038467186.1  signal transducer and activator of transcription 3 isoform X1

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  2. XM_038611259.1 → XP_038467187.1  signal transducer and activator of transcription 3 isoform X1

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  3. XM_038611254.1 → XP_038467182.1  signal transducer and activator of transcription 3 isoform X1

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  4. XM_038611256.1 → XP_038467184.1  signal transducer and activator of transcription 3 isoform X3

    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  5. XM_038611255.1 → XP_038467183.1  signal transducer and activator of transcription 3 isoform X2

    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  6. XM_038611257.1 → XP_038467185.1  signal transducer and activator of transcription 3 isoform X4

    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    20413942..20489100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547288.1 → XP_038403216.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  2. XM_038547289.1 → XP_038403217.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  3. XM_038547284.1 → XP_038403212.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  4. XM_038547286.1 → XP_038403214.1  signal transducer and activator of transcription 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I3N7F2, A0A8P0P0B7
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  5. XM_038547285.1 → XP_038403213.1  signal transducer and activator of transcription 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N7S6
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  6. XM_038547287.1 → XP_038403215.1  signal transducer and activator of transcription 3 isoform X4

    UniProtKB/TrEMBL
    A0A8I3N7F2, A0A8P0P0B7
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    20001678..20076249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005624457.4 → XP_005624514.1  signal transducer and activator of transcription 3 isoform X1

    See identical proteins and their annotated locations for XP_005624514.1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  2. XM_005624458.4 → XP_005624515.1  signal transducer and activator of transcription 3 isoform X1

    See identical proteins and their annotated locations for XP_005624515.1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  3. XM_022422981.2 → XP_022278689.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMX1, A0A8C0QJT6, A0A8I3N7S6, A0A8I3RV66
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  4. XM_022422983.2 → XP_022278691.1  signal transducer and activator of transcription 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I3N7F2, A0A8P0P0B7
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  5. XM_022422982.2 → XP_022278690.1  signal transducer and activator of transcription 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N7S6
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  6. XM_022422984.2 → XP_022278692.1  signal transducer and activator of transcription 3 isoform X4

    UniProtKB/TrEMBL
    A0A8I3N7F2, A0A8P0P0B7
    Conserved Domains (4) summary
    cd10374
    Location:554 → 714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
Nucleotide Protein
Heading Accession and Version

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