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HDAC5 histone deacetylase 5 [ Canis lupus familiaris (dog) ]

Gene ID: 490941, updated on 5-Mar-2024

Summary

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Official Symbol
HDAC5provided by VGNC
Official Full Name
histone deacetylase 5provided by VGNC
Primary source
VGNC:VGNC:49093
See related
Ensembl:ENSCAFG00845009404
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (19957058..19992997)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (18651855..18687786)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (19138202..19174140)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (18810173..18846100)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (18993422..19029330)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 16 Neighboring gene homologous recombination factor with OB-fold Neighboring gene glucose-6-phosphatase catalytic subunit 3 Neighboring gene LSM12 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 5
XP_005624466.1
XP_005624467.1
XP_013971996.1
XP_013971998.1
XP_022278619.1
XP_022278620.1
XP_022278621.1
XP_038341300.1
XP_038341301.1
XP_038341302.1
XP_038341303.1
XP_038341304.1
XP_038341305.1
XP_038341306.1
XP_038403066.1
XP_038403067.1
XP_038403068.1
XP_038403069.1
XP_038403070.1
XP_038403071.1
XP_038403072.1
XP_038467036.1
XP_038467037.1
XP_038467038.1
XP_038467039.1
XP_038467040.1
XP_038467041.1
XP_038467042.1
XP_038532219.1
XP_038532220.1
XP_038532221.1
XP_038532222.1
XP_038532223.1
XP_038532224.1
XP_038532225.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    19957058..19992997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676295.1 → XP_038532223.1  histone deacetylase 5 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8I3RV81, A0A8P0TI77
    Related
    ENSCAFP00845012916.1, ENSCAFT00845016606.1
    Conserved Domains (2) summary
    cd10007
    Location:664 → 1080
    HDAC5; Histone deacetylase 5
    cl25407
    Location:59 → 146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  2. XM_038676296.1 → XP_038532224.1  histone deacetylase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0Z0C0
    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  3. XM_038676292.1 → XP_038532220.1  histone deacetylase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0RBA0
    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  4. XM_038676297.1 → XP_038532225.1  histone deacetylase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0Z0C0
    Related
    ENSCAFP00845013191.1, ENSCAFT00845016944.1
    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  5. XM_038676294.1 → XP_038532222.1  histone deacetylase 5 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8I3RV93, A0A8P0THK9
    Related
    ENSCAFP00845013001.1, ENSCAFT00845016706.1
    Conserved Domains (2) summary
    cd10007
    Location:673 → 1089
    HDAC5; Histone deacetylase 5
    cl25407
    Location:68 → 155
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  6. XM_038676293.1 → XP_038532221.1  histone deacetylase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0RBA0
    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  7. XM_038676291.1 → XP_038532219.1  histone deacetylase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDF0
    Conserved Domains (2) summary
    cd10007
    Location:692 → 1108
    HDAC5; Histone deacetylase 5
    cl25407
    Location:87 → 174
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    18810173..18846100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485376.1 → XP_038341304.1  histone deacetylase 5 isoform X4

    Conserved Domains (2) summary
    cd10007
    Location:664 → 1080
    HDAC5; Histone deacetylase 5
    cl25407
    Location:59 → 146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  2. XM_038485377.1 → XP_038341305.1  histone deacetylase 5 isoform X5

    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  3. XM_038485373.1 → XP_038341301.1  histone deacetylase 5 isoform X2

    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  4. XM_038485378.1 → XP_038341306.1  histone deacetylase 5 isoform X5

    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  5. XM_038485375.1 → XP_038341303.1  histone deacetylase 5 isoform X3

    Conserved Domains (2) summary
    cd10007
    Location:673 → 1089
    HDAC5; Histone deacetylase 5
    cl25407
    Location:68 → 155
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  6. XM_038485374.1 → XP_038341302.1  histone deacetylase 5 isoform X2

    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  7. XM_038485372.1 → XP_038341300.1  histone deacetylase 5 isoform X1

    Conserved Domains (2) summary
    cd10007
    Location:692 → 1108
    HDAC5; Histone deacetylase 5
    cl25407
    Location:87 → 174
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    18993422..19029330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611112.1 → XP_038467040.1  histone deacetylase 5 isoform X4

    Conserved Domains (2) summary
    cd10007
    Location:664 → 1080
    HDAC5; Histone deacetylase 5
    cl25407
    Location:59 → 146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  2. XM_038611113.1 → XP_038467041.1  histone deacetylase 5 isoform X5

    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  3. XM_038611109.1 → XP_038467037.1  histone deacetylase 5 isoform X2

    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  4. XM_038611114.1 → XP_038467042.1  histone deacetylase 5 isoform X5

    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  5. XM_038611111.1 → XP_038467039.1  histone deacetylase 5 isoform X3

    Conserved Domains (2) summary
    cd10007
    Location:673 → 1089
    HDAC5; Histone deacetylase 5
    cl25407
    Location:68 → 155
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  6. XM_038611110.1 → XP_038467038.1  histone deacetylase 5 isoform X2

    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  7. XM_038611108.1 → XP_038467036.1  histone deacetylase 5 isoform X1

    Conserved Domains (2) summary
    cd10007
    Location:692 → 1108
    HDAC5; Histone deacetylase 5
    cl25407
    Location:87 → 174
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    19138202..19174140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547142.1 → XP_038403070.1  histone deacetylase 5 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8I3RV81, A0A8P0TI77
    Conserved Domains (2) summary
    cd10007
    Location:664 → 1080
    HDAC5; Histone deacetylase 5
    cl25407
    Location:59 → 146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  2. XM_038547143.1 → XP_038403071.1  histone deacetylase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0Z0C0
    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  3. XM_038547139.1 → XP_038403067.1  histone deacetylase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0RBA0
    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  4. XM_038547144.1 → XP_038403072.1  histone deacetylase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0Z0C0
    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  5. XM_038547141.1 → XP_038403069.1  histone deacetylase 5 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8I3RV93, A0A8P0THK9
    Conserved Domains (2) summary
    cd10007
    Location:673 → 1089
    HDAC5; Histone deacetylase 5
    cl25407
    Location:68 → 155
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  6. XM_038547140.1 → XP_038403068.1  histone deacetylase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0RBA0
    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  7. XM_038547138.1 → XP_038403066.1  histone deacetylase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDF0
    Conserved Domains (2) summary
    cd10007
    Location:692 → 1108
    HDAC5; Histone deacetylase 5
    cl25407
    Location:87 → 174
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18651855..18687786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014116523.3 → XP_013971998.1  histone deacetylase 5 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8I3RV81, A0A8P0TI77
    Conserved Domains (2) summary
    cd10007
    Location:664 → 1080
    HDAC5; Histone deacetylase 5
    cl25407
    Location:59 → 146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  2. XM_022422912.2 → XP_022278620.1  histone deacetylase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0Z0C0
    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  3. XM_005624409.4 → XP_005624466.1  histone deacetylase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0RBA0
    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  4. XM_022422913.2 → XP_022278621.1  histone deacetylase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0Z0C0
    Conserved Domains (2) summary
    cd10007
    Location:647 → 1063
    HDAC5; Histone deacetylase 5
    cl25407
    Location:42 → 129
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  5. XM_005624410.4 → XP_005624467.1  histone deacetylase 5 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8I3RV93, A0A8P0THK9
    Conserved Domains (2) summary
    cd10007
    Location:673 → 1089
    HDAC5; Histone deacetylase 5
    cl25407
    Location:68 → 155
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  6. XM_022422911.2 → XP_022278619.1  histone deacetylase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDF0, A0A8C0RBA0
    Conserved Domains (2) summary
    cd10007
    Location:674 → 1090
    HDAC5; Histone deacetylase 5
    cl25407
    Location:69 → 156
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  7. XM_014116521.3 → XP_013971996.1  histone deacetylase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDF0
    Conserved Domains (2) summary
    cd10007
    Location:692 → 1108
    HDAC5; Histone deacetylase 5
    cl25407
    Location:87 → 174
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
Nucleotide Protein
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