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MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Canis lupus familiaris (dog) ]

Gene ID: 490926, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K14provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 14provided by VGNC
Primary source
VGNC:VGNC:42970
See related
Ensembl:ENSCAFG00845005731
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (18928453..18975466)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (17640218..17687188)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (18141265..18188242)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (17806803..17853778)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (17985479..18032427)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 27 Neighboring gene uncharacterized LOC119876636 Neighboring gene uncharacterized LOC106559274 Neighboring gene uncharacterized LOC111097342 Neighboring gene spermatogenesis associated 32 Neighboring gene uncharacterized LOC119873262 Neighboring gene formin like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappaB pathways. Luo SF, et al. Cell Signal, 2006 Aug. PMID 16278065

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that phosphorylation and expression of cPLA2 correlates with the release of PGE2 from LPS-challenged TSMCs, at least in part, mediated through MAPKs and NF-kappaB signaling pathways.
    Title: Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappaB pathways.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 14
XP_038341203.1
XP_038341204.1
XP_038402971.1
XP_038402972.1
XP_038466923.1
XP_038466924.1
XP_038484734.1
XP_038532114.1
XP_038532115.1
XP_548049.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    18928453..18975466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676186.1 → XP_038532114.1  mitogen-activated protein kinase kinase kinase 14

    UniProtKB/TrEMBL
    A0A8C0JYX8, A0A8C0MFD3, A0A8C0MLF4, A0A8C0QVU3, A0A8I3MS86, A0A8I3N0Q6
    Related
    ENSCAFP00845007949.1, ENSCAFT00845010199.1
    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

  2. XM_038676187.1 → XP_038532115.1  mitogen-activated protein kinase kinase kinase 14

    UniProtKB/TrEMBL
    A0A8C0JYX8, A0A8C0MFD3, A0A8C0MLF4, A0A8C0QVU3, A0A8I3MS86, A0A8I3N0Q6
    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    17806803..17853778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485275.1 → XP_038341203.1  mitogen-activated protein kinase kinase kinase 14

    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

  2. XM_038485276.1 → XP_038341204.1  mitogen-activated protein kinase kinase kinase 14

    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    17985479..18032427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038610995.1 → XP_038466923.1  mitogen-activated protein kinase kinase kinase 14

    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

  2. XM_038610996.1 → XP_038466924.1  mitogen-activated protein kinase kinase kinase 14

    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    18141265..18188242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547043.1 → XP_038402971.1  mitogen-activated protein kinase kinase kinase 14

    UniProtKB/TrEMBL
    A0A8C0JYX8, A0A8C0MFD3, A0A8C0MLF4, A0A8C0QVU3, A0A8I3MS86, A0A8I3N0Q6
    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

  2. XM_038547044.1 → XP_038402972.1  mitogen-activated protein kinase kinase kinase 14

    UniProtKB/TrEMBL
    A0A8C0JYX8, A0A8C0MFD3, A0A8C0MLF4, A0A8C0QVU3, A0A8I3MS86, A0A8I3N0Q6
    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    17640218..17687188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_548049.7 → XP_548049.3  mitogen-activated protein kinase kinase kinase 14

    UniProtKB/TrEMBL
    A0A8C0JYX8, A0A8C0MFD3, A0A8C0MLF4, A0A8C0QVU3, A0A8I3MS86, A0A8I3N0Q6
    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

  2. XM_038628806.1 → XP_038484734.1  mitogen-activated protein kinase kinase kinase 14

    UniProtKB/TrEMBL
    A0A8C0JYX8, A0A8C0MFD3, A0A8C0MLF4, A0A8C0QVU3, A0A8I3MS86, A0A8I3N0Q6
    Conserved Domains (1) summary
    cd13991
    Location:394 → 661
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)
Nucleotide Protein
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