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PRKCA protein kinase C alpha [ Canis lupus familiaris (dog) ]

Gene ID: 490904, updated on 5-Mar-2024

Summary

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Official Symbol
PRKCAprovided by VGNC
Official Full Name
protein kinase C alphaprovided by VGNC
Primary source
VGNC:VGNC:44978
See related
Ensembl:ENSCAFG00845027678
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (15300837..15695928, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (14532025..14927673, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (12891959..13287663)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (14247910..14642594, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (12891369..13286136)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 4 Neighboring gene uncharacterized LOC102154199 Neighboring gene uncharacterized LOC106559242 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111097324 Neighboring gene uncharacterized LOC111097325 Neighboring gene alanine and glycine-rich protein-like Neighboring gene uncharacterized LOC119873256 Neighboring gene apolipoprotein H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactive role of protein phosphatase 2A and protein kinase Calpha in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery. Obara K, et al. J Vasc Res, 2010. PMID 19729958
  2. A biosensor of local kinesin activity reveals roles of PKC and EB1 in KIF17 activation. Espenel C, et al. J Cell Biol, 2013 Nov 11. PMID 24189273, Free PMC Article
  3. PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells. Padovano V, et al. Am J Physiol Cell Physiol, 2009 Oct. PMID 19605734
  4. Activation of protein kinase C-α and Src kinase increases urea transporter A1 α-2, 6 sialylation. Li X, et al. J Am Soc Nephrol, 2015 Apr. PMID 25300290, Free PMC Article
  5. Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells. Hong SH, et al. Vet Comp Oncol, 2011 Sep. PMID 21848623, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. regulates UT-A1 function by increasing glycan sialylation through Src kinase pathways
    Title: Activation of protein kinase C-α and Src kinase increases urea transporter A1 α-2, 6 sialylation.
  2. we demonstrate that PKC contributes to the activation of KIF17 and that this is required for KIF17 to stabilize microtubules in epithelia.
    Title: A biosensor of local kinesin activity reveals roles of PKC and EB1 in KIF17 activation.
  3. This study demonstrated, using four newly established canine osteosarcoma cell lines, that protein kinase C (PKC) alpha, PKC gamma, and PKC iota are responsible for the phosphorylation of ezrin and cell migration in canine osteosarcoma cells.
    Title: Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells.
  4. OATP2B1/SLCO2B1 function is modulated by protein kinase C-mediated internalization
    Title: Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.
  5. Activation of vascular PKCalpha mediated by an inhibitor of PP2A is involved in the stretch-induced triphosphorylation of myosin light chain, and this triphosphorylation counteracts the stretch-induced contraction.
    Title: Interactive role of protein phosphatase 2A and protein kinase Calpha in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery.
  6. PKC activity regulates EAAC1 surface density in MDCK cells by inducing its internalization and retention in PKCalpha-labeled recycling endosomes common to apical and basolateral proteins.
    Title: PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells.
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Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C alpha type
XP_038341139.1
XP_038341140.1
XP_038402732.1
XP_038402733.1
XP_038466720.1
XP_038466721.1
XP_038484109.1
XP_038484119.1
XP_038532001.1
XP_038532002.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    15300837..15695928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676073.1 → XP_038532001.1  protein kinase C alpha type isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQP1, A0A8C0T8H0, A0A8I3PUQ8
    Related
    ENSCAFP00845038825.1, ENSCAFT00845049488.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038676074.1 → XP_038532002.1  protein kinase C alpha type isoform X2

    UniProtKB/TrEMBL
    A0A8C0LQP1, A0A8C0Z373, A0A8I3PYN4
    Related
    ENSCAFP00845038315.1, ENSCAFT00845048835.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    14247910..14642594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485211.1 → XP_038341139.1  protein kinase C alpha type isoform X1

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038485212.1 → XP_038341140.1  protein kinase C alpha type isoform X2

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    12891369..13286136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038610792.1 → XP_038466720.1  protein kinase C alpha type isoform X1

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038610793.1 → XP_038466721.1  protein kinase C alpha type isoform X2

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    12891959..13287663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038546804.1 → XP_038402732.1  protein kinase C alpha type isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQP1, A0A8C0T8H0, A0A8I3PUQ8
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038546805.1 → XP_038402733.1  protein kinase C alpha type isoform X2

    UniProtKB/TrEMBL
    A0A8C0LQP1, A0A8C0Z373, A0A8I3PYN4
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    14532025..14927673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038628181.1 → XP_038484109.1  protein kinase C alpha type isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQP1, A0A8C0T8H0, A0A8I3PUQ8
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038628191.1 → XP_038484119.1  protein kinase C alpha type isoform X2

    UniProtKB/TrEMBL
    A0A8C0LQP1, A0A8C0Z373, A0A8I3PYN4
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
Nucleotide Protein
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