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JAG2 jagged canonical Notch ligand 2 [ Canis lupus familiaris (dog) ]

Gene ID: 490882, updated on 5-Mar-2024

Summary

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Official Symbol
JAG2provided by VGNC
Official Full Name
jagged canonical Notch ligand 2provided by VGNC
Primary source
VGNC:VGNC:42173
See related
Ensembl:ENSCAFG00845022668
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (72823360..72848984, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (72047599..72068957, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (72944852..72966232, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (72503851..72525225, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (72554984..72576363, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 4 Neighboring gene G protein-coupled receptor 132 Neighboring gene nudix hydrolase 14 Neighboring gene formin-like protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein jagged-2; LOW QUALITY PROTEIN: protein jagged-2
Names
jagged 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    72823360..72848984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038673017.1 → XP_038528945.1  protein jagged-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PPX5
    Related
    ENSCAFP00845031359.1, ENSCAFT00845040047.1
    Conserved Domains (6) summary
    smart00215
    Location:1118 → 1189
    VWC_out; von Willebrand factor (vWF) type C domain
    PHA03247
    Location:2 → 141
    PHA03247; large tegument protein UL36; Provisional
    cd00054
    Location:552 → 590
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:596 → 626
    EGF; EGF-like domain
    pfam01414
    Location:423 → 485
    DSL; Delta serrate ligand
    pfam07657
    Location:268 → 343
    MNNL; N-terminus of Notch ligand

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    72503851..72525225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038484386.1 → XP_038340314.1  LOW QUALITY PROTEIN: protein jagged-2 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    72554984..72576363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038609990.1 → XP_038465918.1  protein jagged-2 isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    72944852..72966232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038545932.1 → XP_038401860.1  protein jagged-2 isoform X4

    UniProtKB/TrEMBL
    A0A8P0NJU2
    Conserved Domains (5) summary
    smart00215
    Location:873 → 944
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:307 → 345
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:351 → 381
    EGF; EGF-like domain
    pfam01414
    Location:178 → 240
    DSL; Delta serrate ligand
    pfam07657
    Location:23 → 98
    MNNL; N-terminus of Notch ligand

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    72047599..72068957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038597065.1 → XP_038452993.1  protein jagged-2 isoform X5

    UniProtKB/TrEMBL
    A0A8P0NJU2
    Conserved Domains (5) summary
    smart00215
    Location:873 → 944
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:307 → 345
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:351 → 381
    EGF; EGF-like domain
    pfam01414
    Location:178 → 240
    DSL; Delta serrate ligand
    pfam07657
    Location:23 → 98
    MNNL; N-terminus of Notch ligand
Nucleotide Protein
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