PRKCH protein kinase C eta [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PRKCHprovided by VGNC
Official Full Name: protein kinase C etaprovided by VGNC
Primary source: VGNC:VGNC:44981
See related: Ensembl:ENSCAFG00845023062
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	8	NC_051812.1 (36452192..36686164)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	8	NC_006590.4 (35972166..36205993)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	8	NC_049229.1 (36501849..36735387)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	8	NC_049268.1 (36062559..36296413)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	8	NC_049749.1 (36139874..36373616)

Chromosome 8 - NC_051812.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKC eta directly interacts with the C-terminal domain of occludin and phosphorylates it on highly conserved T403 and T404, an important mechanism of epithelial TJ regulation by PKC eta.
Title: PKC eta regulates occludin phosphorylation and epithelial tight junction integrity.

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein kinase C eta type

XP_038339349.1

EC 2.7.11.13

XP_038400813.1

EC 2.7.11.13

XP_038464926.1

EC 2.7.11.13

XP_038529731.1

EC 2.7.11.13

XP_547844.2

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051812.1 Reference ROS_Cfam_1.0

Range

36452192..36686164

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038673803.1 → XP_038529731.1 protein kinase C eta type

UniProtKB/TrEMBL

A0A8C0PBQ1, A0A8C0RXK0, A0A8I3PGY9

Related

ENSCAFP00845031872.1, ENSCAFT00845040718.1

Conserved Domains (4) summary

cd04014
Location:8 → 140

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

cd05590
Location:359 → 681

STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta

cd20835
Location:166 → 226

C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

cd20838
Location:244 → 298

C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

NC_049268.1 Alternate UMICH_Zoey_3.1

Range

36062559..36296413

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038483421.1 → XP_038339349.1 protein kinase C eta type

Conserved Domains (4) summary

cd04014
Location:8 → 140

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

cd05590
Location:359 → 681

STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta

cd20835
Location:166 → 226

C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

cd20838
Location:244 → 298

C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049749.1 Alternate UNSW_CanFamBas_1.0

Range

36139874..36373616

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038608998.1 → XP_038464926.1 protein kinase C eta type

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049229.1 Alternate UU_Cfam_GSD_1.0

Range

36501849..36735387

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038544885.1 → XP_038400813.1 protein kinase C eta type

UniProtKB/TrEMBL

A0A8C0PBQ1, A0A8C0PJV6, A0A8P0NH77

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

35972166..36205993

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_547844.7 → XP_547844.2 protein kinase C eta type

UniProtKB/TrEMBL

A0A8C0PBQ1, A0A8C0PJV6, A0A8P0NH77

Conserved Domains (4) summary

cd04014
Location:8 → 140

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

smart00220
Location:355 → 614

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05590
Location:359 → 681

STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta

pfam00130
Location:246 → 298

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)