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BMP4 bone morphogenetic protein 4 [ Canis lupus familiaris (dog) ]

Gene ID: 490695, updated on 5-Mar-2024

Summary

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Official Symbol
BMP4provided by VGNC
Official Full Name
bone morphogenetic protein 4provided by VGNC
Primary source
VGNC:VGNC:38480
See related
Ensembl:ENSCAFG00845004370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
35
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (30252884..30601864, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (29765711..29772707, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (30299531..30306532, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (29856480..29863475, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (29933754..29940734, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097219 Neighboring gene 60S ribosomal protein L17-like Neighboring gene ferritin heavy chain-like Neighboring gene dnaJ homolog subfamily A member 1-like Neighboring gene rho-related GTP-binding protein RhoG-like Neighboring gene cyclin dependent kinase inhibitor 3 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene glia maturation factor beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional role of bone morphogenetic protein-4 in isolated canine parietal cells. Nitsche H, et al. Am J Physiol Gastrointest Liver Physiol, 2007 Sep. PMID 17600042

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BMP-4 promotes the induction and maintenance of a differentiated parietal cell phenotype.
    Title: Functional role of bone morphogenetic protein-4 in isolated canine parietal cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables BMP receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bone morphogenetic protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287170.2 → NP_001274099.1  bone morphogenetic protein 4 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAAUVH010000053
    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Related
    ENSCAFP00845006209.1, ENSCAFT00845007854.1
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    30252884..30601864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672910.1 → XP_038528838.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038672914.1 → XP_038528842.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  3. XM_038672911.1 → XP_038528839.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  4. XM_038672899.1 → XP_038528827.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  5. XM_038672898.1 → XP_038528826.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  6. XM_038672900.1 → XP_038528828.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  7. XM_038672906.1 → XP_038528834.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  8. XM_038672907.1 → XP_038528835.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  9. XM_038672905.1 → XP_038528833.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  10. XM_038672901.1 → XP_038528829.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  11. XM_038672897.1 → XP_038528825.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  12. XM_038672903.1 → XP_038528831.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  13. XM_038672902.1 → XP_038528830.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  14. XM_038672913.1 → XP_038528841.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  15. XM_038672909.1 → XP_038528837.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  16. XM_038672912.1 → XP_038528840.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  17. XM_038672908.1 → XP_038528836.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  18. XM_038672904.1 → XP_038528832.1  bone morphogenetic protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3L7, A0A8C0M2B6, A0A8I3MKS3, Q9MZV5
    Conserved Domains (2) summary
    cd19391
    Location:303 → 409
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

  19. XM_038672896.1 → XP_038528824.1  bone morphogenetic protein 4 isoform X1

    Conserved Domains (2) summary
    cd19391
    Location:350 → 456
    TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
    pfam00688
    Location:88 → 323
    TGFb_propeptide; TGF-beta propeptide

RNA

  1. XR_005430542.1 RNA Sequence

  2. XR_005430533.1 RNA Sequence

  3. XR_005430530.1 RNA Sequence

  4. XR_005430529.1 RNA Sequence

  5. XR_005430519.1 RNA Sequence

  6. XR_005430524.1 RNA Sequence

  7. XR_005430518.1 RNA Sequence

  8. XR_005430516.1 RNA Sequence

  9. XR_005430514.1 RNA Sequence

  10. XR_005430515.1 RNA Sequence

  11. XR_005430537.1 RNA Sequence

  12. XR_005430520.1 RNA Sequence

  13. XR_005430536.1 RNA Sequence

  14. XR_005430522.1 RNA Sequence

  15. XR_005430517.1 RNA Sequence

  16. XR_005430532.1 RNA Sequence

  17. XR_005430528.1 RNA Sequence

  18. XR_005430527.1 RNA Sequence

  19. XR_005430513.1 RNA Sequence

  20. XR_005430521.1 RNA Sequence

  21. XR_005430538.1 RNA Sequence

  22. XR_005430525.1 RNA Sequence

  23. XR_005430534.1 RNA Sequence

  24. XR_005430531.1 RNA Sequence

  25. XR_005430539.1 RNA Sequence

  26. XR_005430523.1 RNA Sequence

  27. XR_005430526.1 RNA Sequence

  28. XR_005430535.1 RNA Sequence

  29. XR_005430541.1 RNA Sequence

  30. XR_005430540.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    29856480..29863475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    29933754..29940734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    30299531..30306532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    29765711..29772707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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