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PKN2 protein kinase N2 [ Canis lupus familiaris (dog) ]

Gene ID: 490174, updated on 5-Mar-2024

Summary

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Official Symbol
PKN2provided by VGNC
Official Full Name
protein kinase N2provided by VGNC
Primary source
VGNC:VGNC:44612
See related
Ensembl:ENSCAFG00845018917
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (60067704..60197746, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (62264725..62394692, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (60074127..60204202, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (59633009..59762681, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (59588332..59718360, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene RING-box protein 2-like Neighboring gene general transcription factor IIB Neighboring gene serine/arginine-rich splicing factor 10-like Neighboring gene tubulin alpha-1A chain-like Neighboring gene uncharacterized LOC119872361

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase N2
XP_038336062.1
XP_038336063.1
XP_038397386.1
XP_038397387.1
XP_038411800.1
XP_038411808.1
XP_038461523.1
XP_038461524.1
XP_038526136.1
XP_038526137.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    60067704..60197746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038670209.1 → XP_038526137.1  serine/threonine-protein kinase N2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NSX8, A0A8C0NTL9, A0A8I3PD08, A0A8I3PG00, A0A8P0T1K1
    Related
    ENSCAFP00845026454.1, ENSCAFT00845033804.1
    Conserved Domains (5) summary
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:608 → 933
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:127 → 201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:389 → 471
    C2; C2 domain

  2. XM_038670208.1 → XP_038526136.1  serine/threonine-protein kinase N2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSX8, A0A8C0QCS3, A0A8I3NX96, A0A8I3PD08, A0A8P0T1K1
    Related
    ENSCAFP00845026288.1, ENSCAFT00845033580.1
    Conserved Domains (5) summary
    cd08687
    Location:389 → 472
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:127 → 201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:656 → 981
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    59633009..59762681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038480135.1 → XP_038336063.1  serine/threonine-protein kinase N2 isoform X2

    Conserved Domains (5) summary
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:608 → 933
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:127 → 201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:389 → 471
    C2; C2 domain

  2. XM_038480134.1 → XP_038336062.1  serine/threonine-protein kinase N2 isoform X1

    Conserved Domains (5) summary
    cd08687
    Location:389 → 472
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:127 → 201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:656 → 981
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    59588332..59718360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038605596.1 → XP_038461524.1  serine/threonine-protein kinase N2 isoform X2

    Conserved Domains (5) summary
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:608 → 933
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:127 → 201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:389 → 471
    C2; C2 domain

  2. XM_038605595.1 → XP_038461523.1  serine/threonine-protein kinase N2 isoform X1

    Conserved Domains (5) summary
    cd08687
    Location:389 → 472
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:127 → 201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:656 → 981
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    60074127..60204202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038541459.1 → XP_038397387.1  serine/threonine-protein kinase N2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NSX8, A0A8C0NTL9, A0A8I3PD08, A0A8I3PG00, A0A8P0T1K1
    Conserved Domains (5) summary
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:608 → 933
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:127 → 201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:389 → 471
    C2; C2 domain

  2. XM_038541458.1 → XP_038397386.1  serine/threonine-protein kinase N2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSX8, A0A8C0QCS3, A0A8I3NX96, A0A8I3PD08, A0A8P0T1K1
    Conserved Domains (5) summary
    cd08687
    Location:389 → 472
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:127 → 201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:656 → 981
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    62264725..62394692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038555880.1 → XP_038411808.1  serine/threonine-protein kinase N2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NSX8, A0A8C0NTL9, A0A8I3PD08, A0A8I3PG00, A0A8P0T1K1
    Conserved Domains (5) summary
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:608 → 933
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:127 → 201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:389 → 471
    C2; C2 domain

  2. XM_038555872.1 → XP_038411800.1  serine/threonine-protein kinase N2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSX8, A0A8C0QCS3, A0A8I3NX96, A0A8I3PD08, A0A8P0T1K1
    Conserved Domains (5) summary
    cd08687
    Location:389 → 472
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42 → 107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:127 → 201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209 → 282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:656 → 981
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
Nucleotide Protein
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