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PRKCB protein kinase C beta [ Canis lupus familiaris (dog) ]

Gene ID: 489968, updated on 5-Mar-2024

Summary

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Official Symbol
PRKCBprovided by VGNC
Official Full Name
protein kinase C betaprovided by VGNC
Primary source
VGNC:VGNC:49947
See related
Ensembl:ENSCAFG00845001335
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PRKCB1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (21880650..22206417, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (23304828..23630068, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (21982425..22308075, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (21685773..22010753, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (21587647..21912745, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096274 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 3 Neighboring gene uncharacterized LOC119872178 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC119872330 Neighboring gene calcineurin like EF-hand protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells. Ikari A, et al. J Cell Physiol, 2015 Nov. PMID 25825272

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C beta type
Names
protein kinase C, beta 1
XP_038334708.1
XP_038334709.1
XP_038395955.1
XP_038395956.1
XP_038400339.1
XP_038400347.1
XP_038460032.1
XP_038460033.1
XP_038524754.1
XP_038524755.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    21880650..22206417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668827.1 → XP_038524755.1  protein kinase C beta type isoform X2

    UniProtKB/TrEMBL
    A0A8C0L9E9, A0A8C0RWR6, A0A8I3MFL8
    Related
    ENSCAFP00845001827.1, ENSCAFT00845002305.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 664
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038668826.1 → XP_038524754.1  protein kinase C beta type isoform X1

    UniProtKB/TrEMBL
    A0A8C0P860, A0A8C0PWS9, A0A8I3MI53
    Related
    ENSCAFP00845001838.1, ENSCAFT00845002318.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 663
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    21685773..22010753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038478781.1 → XP_038334709.1  protein kinase C beta type isoform X2

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 664
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038478780.1 → XP_038334708.1  protein kinase C beta type isoform X1

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 663
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    21587647..21912745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604105.1 → XP_038460033.1  protein kinase C beta type isoform X2

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 664
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038604104.1 → XP_038460032.1  protein kinase C beta type isoform X1

    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 663
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    21982425..22308075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540028.1 → XP_038395956.1  protein kinase C beta type isoform X2

    UniProtKB/TrEMBL
    A0A8C0L9E9, A0A8C0RWR6, A0A8I3MFL8
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 664
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038540027.1 → XP_038395955.1  protein kinase C beta type isoform X1

    UniProtKB/TrEMBL
    A0A8C0P860, A0A8C0PWS9, A0A8I3MI53
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 663
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23304828..23630068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544419.1 → XP_038400347.1  protein kinase C beta type isoform X2

    UniProtKB/TrEMBL
    A0A8C0L9E9, A0A8C0RWR6, A0A8I3MFL8
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 664
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. XM_038544411.1 → XP_038400339.1  protein kinase C beta type isoform X1

    UniProtKB/TrEMBL
    A0A8C0P860, A0A8C0PWS9, A0A8I3MI53
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341 → 663
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:35 → 92
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102 → 155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
Nucleotide Protein
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