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ITGAM integrin subunit alpha M [ Canis lupus familiaris (dog) ]

Gene ID: 489928, updated on 5-Mar-2024

Summary

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Official Symbol
ITGAMprovided by VGNC
Official Full Name
integrin subunit alpha Mprovided by VGNC
Primary source
VGNC:VGNC:42133
See related
Ensembl:ENSCAFG00845011550
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (17068771..17127224, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (18516000..18571559, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (17102490..17158038, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (16871848..16927654, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (16791010..16846822, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene integrin alpha-D-like Neighboring gene integrin subunit alpha X Neighboring gene ubiquitin-conjugating enzyme E2 C-like Neighboring gene prefoldin subunit 4-like Neighboring gene uncharacterized LOC119872173 Neighboring gene uncharacterized LOC119872172 Neighboring gene ORM1-like protein 2 Neighboring gene tripartite motif containing 72

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-M

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    17068771..17127224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668539.1 → XP_038524467.1  integrin alpha-M isoform X3

    UniProtKB/TrEMBL
    A0A8C0L2J8, A0A8I3NIY0
    Related
    ENSCAFP00845016364.1, ENSCAFT00845020843.1
    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1059 → 1073
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  2. XM_038668538.1 → XP_038524466.1  integrin alpha-M isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2J8, A0A8I3NJF7
    Related
    ENSCAFP00845016275.1, ENSCAFT00845020748.1
    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1094 → 1107
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  3. XM_038668537.1 → XP_038524465.1  integrin alpha-M isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2J8, A0A8C0M9J9, A0A8I3NV00
    Related
    ENSCAFP00845016081.1, ENSCAFT00845020510.1
    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1130 → 1144
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    16871848..16927654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038478481.1 → XP_038334409.1  integrin alpha-M isoform X3

    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1059 → 1073
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  2. XM_038478480.1 → XP_038334408.1  integrin alpha-M isoform X2

    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1094 → 1107
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  3. XM_038478479.1 → XP_038334407.1  integrin alpha-M isoform X1

    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1130 → 1144
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    16791010..16846822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038603821.1 → XP_038459749.1  integrin alpha-M isoform X3

    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1059 → 1073
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  2. XM_038603820.1 → XP_038459748.1  integrin alpha-M isoform X2

    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1094 → 1107
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  3. XM_038603819.1 → XP_038459747.1  integrin alpha-M isoform X1

    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1130 → 1144
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    17102490..17158038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038539736.1 → XP_038395664.1  integrin alpha-M isoform X3

    UniProtKB/TrEMBL
    A0A8C0L2J8

  2. XM_038539735.1 → XP_038395663.1  integrin alpha-M isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2J8

  3. XM_038539734.1 → XP_038395662.1  integrin alpha-M isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2J8

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18516000..18571559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014114360.3 → XP_013969835.1  integrin alpha-M isoform X3

    UniProtKB/TrEMBL
    A0A8C0L2J8, A0A8I3NIY0
    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1059 → 1073
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  2. XM_038541967.1 → XP_038397895.1  integrin alpha-M isoform X2

    UniProtKB/TrEMBL
    A0A8C0L2J8, A0A8I3NJF7
    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1094 → 1107
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

  3. XM_005621235.4 → XP_005621292.1  integrin alpha-M isoform X1

    See identical proteins and their annotated locations for XP_005621292.1

    UniProtKB/TrEMBL
    A0A8C0L2J8, A0A8C0M9J9, A0A8I3NV00
    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:150 → 325
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1130 → 1144
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha
Nucleotide Protein
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