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ITGAL integrin subunit alpha L [ Canis lupus familiaris (dog) ]

Gene ID: 489905, updated on 5-Mar-2024

Summary

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Official Symbol
ITGALprovided by VGNC
Official Full Name
integrin subunit alpha Lprovided by VGNC
Primary source
VGNC:VGNC:42132
See related
Ensembl:ENSCAFG00845013917
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (17735141..17775970, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (19178232..19219073, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (17765852..17806699, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (17535332..17576226, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (17450788..17491710, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 764 Neighboring gene uncharacterized LOC102154421 Neighboring gene zinc finger protein 768 Neighboring gene selenophosphate synthetase 2 Neighboring gene dCTP pyrophosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive meningitis-arteritis in dogs. Schwartz M, et al. Vet Immunol Immunopathol, 2008 Dec 15. PMID 18760844

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive meningitis-arteritis in dogs.
    Title: Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive meningitis-arteritis in dogs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-L

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    17735141..17775970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668615.1 → XP_038524543.1  integrin alpha-L isoform X2

    UniProtKB/TrEMBL
    A0A8C0LYN0
    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_038668616.1 → XP_038524544.1  integrin alpha-L isoform X2

    UniProtKB/TrEMBL
    A0A8C0LYN0
    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_038668614.1 → XP_038524542.1  integrin alpha-L isoform X1

    UniProtKB/TrEMBL
    A0A8C0LYN0, A0A8C0SJG3, A0A8I3NS51
    Related
    ENSCAFP00845019686.1, ENSCAFT00845025024.1
    Conserved Domains (4) summary
    smart00191
    Location:515 → 567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1111 → 1125
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:610 → 981
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:153 → 321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    17535332..17576226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038478561.1 → XP_038334489.1  integrin alpha-L isoform X2

    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_038478562.1 → XP_038334490.1  integrin alpha-L isoform X2

    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_038478560.1 → XP_038334488.1  integrin alpha-L isoform X1

    Conserved Domains (4) summary
    smart00191
    Location:515 → 567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1111 → 1125
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:610 → 981
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:153 → 321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    17450788..17491710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038603890.1 → XP_038459818.1  integrin alpha-L isoform X2

    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_038603891.1 → XP_038459819.1  integrin alpha-L isoform X2

    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_038603889.1 → XP_038459817.1  integrin alpha-L isoform X1

    Conserved Domains (4) summary
    smart00191
    Location:515 → 567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1111 → 1125
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:610 → 981
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:153 → 321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    17765852..17806699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038539810.1 → XP_038395738.1  integrin alpha-L isoform X2

    UniProtKB/TrEMBL
    A0A8C0LYN0
    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_038539811.1 → XP_038395739.1  integrin alpha-L isoform X2

    UniProtKB/TrEMBL
    A0A8C0LYN0
    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_038539809.1 → XP_038395737.1  integrin alpha-L isoform X1

    UniProtKB/TrEMBL
    A0A8C0LYN0, A0A8C0SJG3, A0A8I3NS51
    Conserved Domains (4) summary
    smart00191
    Location:515 → 567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1111 → 1125
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:610 → 981
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:153 → 321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19178232..19219073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022419856.2 → XP_022275564.1  integrin alpha-L isoform X2

    UniProtKB/TrEMBL
    A0A8C0LYN0
    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_022419855.2 → XP_022275563.1  integrin alpha-L isoform X2

    UniProtKB/TrEMBL
    A0A8C0LYN0
    Conserved Domains (4) summary
    smart00191
    Location:421 → 473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1017 → 1031
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:516 → 887
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:59 → 227
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_547024.6 → XP_547024.2  integrin alpha-L isoform X1

    UniProtKB/TrEMBL
    A0A8C0LYN0, A0A8C0SJG3, A0A8I3NS51
    Conserved Domains (4) summary
    smart00191
    Location:515 → 567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:1111 → 1125
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:610 → 981
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:153 → 321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
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