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ACHE acetylcholinesterase [ Canis lupus familiaris (dog) ]

Gene ID: 489828, updated on 5-Mar-2024

Summary

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Official Symbol
ACHEprovided by VGNC
Official Full Name
acetylcholinesteraseprovided by VGNC
Primary source
VGNC:VGNC:49076
See related
Ensembl:ENSCAFG00845000697
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (8809869..8815742)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (10580127..10585994)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (8822240..8828117)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (8661436..8668230)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (8640504..8646368)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene mucin-3B-like Neighboring gene mucin-3A-like Neighboring gene UFM1 specific peptidase 1 (inactive) Neighboring gene serrate, RNA effector molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acetylcholinesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetylcholine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in choline metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: acetylcholinesterase; acetylcholinesterase
Names
acetylcholinesterase (Cartwright blood group)
XP_038333900.1
XP_038394109.1
XP_038394111.1
XP_038394119.1
XP_038394129.1
XP_038395157.1
XP_038395158.1
XP_038395159.1
XP_038395160.1
XP_038459237.1
XP_038459238.1
XP_038459239.1
XP_038459240.1
XP_038523942.1
XP_038523943.1
XP_038523944.1
XP_038523945.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    8809869..8815742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668014.1 → XP_038523942.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Related
    ENSCAFP00845000904.1, ENSCAFT00845001183.1
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  2. XM_038668015.1 → XP_038523943.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  3. XM_038668016.1 → XP_038523944.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  4. XM_038668017.1 → XP_038523945.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    8661436..8668230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038477972.1 → XP_038333900.1  LOW QUALITY PROTEIN: acetylcholinesterase isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    8640504..8646368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038603309.1 → XP_038459237.1  acetylcholinesterase isoform X1

    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  2. XM_038603310.1 → XP_038459238.1  acetylcholinesterase isoform X1

    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  3. XM_038603311.1 → XP_038459239.1  acetylcholinesterase isoform X1

    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  4. XM_038603312.1 → XP_038459240.1  acetylcholinesterase isoform X1

    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    8822240..8828117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038539229.1 → XP_038395157.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  2. XM_038539230.1 → XP_038395158.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  3. XM_038539231.1 → XP_038395159.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  4. XM_038539232.1 → XP_038395160.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10580127..10585994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038538181.1 → XP_038394109.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  2. XM_038538183.1 → XP_038394111.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  3. XM_038538191.1 → XP_038394119.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain

  4. XM_038538201.1 → XP_038394129.1  acetylcholinesterase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R083, A0A8I3MGA9, A0A8P0P619
    Conserved Domains (2) summary
    pfam00135
    Location:34 → 560
    COesterase; Carboxylesterase family
    pfam08674
    Location:575 → 608
    AChE_tetra; Acetylcholinesterase tetramerisation domain
Nucleotide Protein
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