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SH2B2 SH2B adaptor protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489820, updated on 5-Mar-2024

Summary

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Gene symbol
SH2B2
Gene description
SH2B adaptor protein 2
See related
Ensembl:ENSCAFG00845004821
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (7615994..7639944, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (9490633..9514600, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (7711487..7735478, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (7584419..7605038, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (7547911..7571843, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102155052 Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC111096200 Neighboring gene cut like homeobox 1 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane receptor protein tyrosine kinase adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen receptor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH2B adapter protein 2; LOW QUALITY PROTEIN: SH2B adapter protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    7615994..7639944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038667977.1 → XP_038523905.1  SH2B adapter protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MTK2
    Conserved Domains (3) summary
    cd10411
    Location:570 → 665
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:357 → 472
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:190 → 246
    Phe_ZIP; Phenylalanine zipper

  2. XM_038667976.1 → XP_038523904.1  SH2B adapter protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MTK2
    Related
    ENSCAFP00845006815.1, ENSCAFT00845008638.1
    Conserved Domains (3) summary
    cd10411
    Location:571 → 666
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:357 → 472
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:190 → 246
    Phe_ZIP; Phenylalanine zipper

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    7584419..7605038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038480467.1 → XP_038336395.1  SH2B adapter protein 2 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    7547911..7571843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038603272.1 → XP_038459200.1  LOW QUALITY PROTEIN: SH2B adapter protein 2 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    7711487..7735478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038539193.1 → XP_038395121.1  SH2B adapter protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MTK2

  2. XM_038539192.1 → XP_038395120.1  SH2B adapter protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MTK2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    9490633..9514600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005620997.4 → XP_005621054.2  SH2B adapter protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MTK2
    Conserved Domains (3) summary
    cd10411
    Location:572 → 667
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:359 → 474
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:192 → 248
    Phe_ZIP; Phenylalanine zipper

  2. XM_005620996.4 → XP_005621053.2  SH2B adapter protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MTK2
    Conserved Domains (3) summary
    cd10411
    Location:573 → 668
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:359 → 474
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:192 → 248
    Phe_ZIP; Phenylalanine zipper
Nucleotide Protein
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