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SKI SKI proto-oncogene [ Canis lupus familiaris (dog) ]

Gene ID: 489610, updated on 5-Mar-2024

Summary

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Official Symbol
SKIprovided by VGNC
Official Full Name
SKI proto-oncogeneprovided by VGNC
Primary source
VGNC:VGNC:46198
See related
Ensembl:ENSCAFG00845016973
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (57347931..57418465)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (57222188..57292743)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (57621138..57691705)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (57339163..57409707)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (57231570..57302105)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene protein kinase C zeta Neighboring gene uncharacterized LOC119871893 Neighboring gene FA core complex associated protein 20 Neighboring gene MORN repeat containing 1 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene peroxisomal biogenesis factor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ski oncogene
Names
v-ski avian sarcoma viral oncogene homolog
v-ski sarcoma viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    57347931..57418465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038666422.1 → XP_038522350.1  ski oncogene isoform X1

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:561 → 732
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  2. XM_038666427.1 → XP_038522355.1  ski oncogene isoform X6

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    COG1196
    Location:561 → 712
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  3. XM_038666424.1 → XP_038522352.1  ski oncogene isoform X3

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:559 → 730
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  4. XM_038666423.1 → XP_038522351.1  ski oncogene isoform X2

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:560 → 731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  5. XM_038666425.1 → XP_038522353.1  ski oncogene isoform X4

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:543 → 714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  6. XM_038666426.1 → XP_038522354.1  ski oncogene isoform X5

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:542 → 713
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  7. XM_038666428.1 → XP_038522356.1  ski oncogene isoform X7

    UniProtKB/TrEMBL
    A0A8C0LZ71, A0A8I3P330
    Related
    ENSCAFP00845023582.1, ENSCAFT00845030062.1
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:540 → 711
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    57339163..57409707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038476541.1 → XP_038332469.1  ski oncogene isoform X1

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:561 → 732
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  2. XM_038476547.1 → XP_038332475.1  ski oncogene isoform X6

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    COG1196
    Location:561 → 712
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  3. XM_038476543.1 → XP_038332471.1  ski oncogene isoform X3

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:559 → 730
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  4. XM_038476542.1 → XP_038332470.1  ski oncogene isoform X2

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:560 → 731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  5. XM_038476545.1 → XP_038332473.1  ski oncogene isoform X4

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:543 → 714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  6. XM_038476546.1 → XP_038332474.1  ski oncogene isoform X5

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:542 → 713
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  7. XM_038476548.1 → XP_038332476.1  ski oncogene isoform X7

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:540 → 711
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    57231570..57302105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038601848.1 → XP_038457776.1  ski oncogene isoform X1

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:561 → 732
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  2. XM_038601853.1 → XP_038457781.1  ski oncogene isoform X6

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    COG1196
    Location:561 → 712
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  3. XM_038601850.1 → XP_038457778.1  ski oncogene isoform X3

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:559 → 730
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  4. XM_038601849.1 → XP_038457777.1  ski oncogene isoform X2

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:560 → 731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  5. XM_038601851.1 → XP_038457779.1  ski oncogene isoform X4

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:543 → 714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  6. XM_038601852.1 → XP_038457780.1  ski oncogene isoform X5

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:542 → 713
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  7. XM_038601854.1 → XP_038457782.1  ski oncogene isoform X7

    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:540 → 711
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    57621138..57691705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038537684.1 → XP_038393612.1  ski oncogene isoform X1

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:561 → 732
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  2. XM_038537689.1 → XP_038393617.1  ski oncogene isoform X6

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    COG1196
    Location:561 → 712
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  3. XM_038537686.1 → XP_038393614.1  ski oncogene isoform X3

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:559 → 730
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  4. XM_038537685.1 → XP_038393613.1  ski oncogene isoform X2

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:560 → 731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  5. XM_038537687.1 → XP_038393615.1  ski oncogene isoform X4

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:543 → 714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  6. XM_038537688.1 → XP_038393616.1  ski oncogene isoform X5

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:542 → 713
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  7. XM_038537690.1 → XP_038393618.1  ski oncogene isoform X7

    UniProtKB/TrEMBL
    A0A8C0KBG4, A0A8C0LZ71, A0A8P0SN90
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:540 → 711
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    57222188..57292743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038522389.1 → XP_038378317.1  ski oncogene isoform X1

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:561 → 732
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  2. XM_038522428.1 → XP_038378356.1  ski oncogene isoform X6

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    COG1196
    Location:561 → 712
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  3. XM_038522409.1 → XP_038378337.1  ski oncogene isoform X3

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:559 → 730
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  4. XM_038522399.1 → XP_038378327.1  ski oncogene isoform X2

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:560 → 731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  5. XM_038522418.1 → XP_038378346.1  ski oncogene isoform X4

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:543 → 714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  6. XM_038522425.1 → XP_038378353.1  ski oncogene isoform X5

    UniProtKB/TrEMBL
    A0A8C0LZ71
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:542 → 713
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins

  7. XM_014113853.2 → XP_013969328.2  ski oncogene isoform X7

    UniProtKB/TrEMBL
    A0A8C0KBG4, A0A8C0LZ71, A0A8P0SN90
    Conserved Domains (3) summary
    smart01046
    Location:217 → 312
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    TIGR02168
    Location:540 → 711
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21083
    Location:91 → 192
    DHD_Ski; Dachshund-homology domain found in Ski and similar proteins
Nucleotide Protein
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