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DVL2 dishevelled segment polarity protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489464, updated on 5-Mar-2024

Summary

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Official Symbol
DVL2provided by VGNC
Official Full Name
dishevelled segment polarity protein 2provided by VGNC
Primary source
VGNC:VGNC:40138
See related
Ensembl:ENSCAFG00845020074
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (32299943..32307523, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (32332631..32340205, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (32401214..32408791, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (32265249..32272821, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (32224284..32231849, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene uncharacterized LOC119871843 Neighboring gene acyl-CoA dehydrogenase very long chain Neighboring gene microRNA mir-324 Neighboring gene PHD finger protein 23 Neighboring gene GABA type A receptor-associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Canine DVL2 variant contributes to brachycephalic phenotype and caudal vertebral anomalies. Niskanen JE, et al. Hum Genet, 2021 Nov. PMID 33599851, Free PMC Article
  2. Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. Mansour TA, et al. PLoS Genet, 2018 Dec. PMID 30521570, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Canine DVL2 variant contributes to brachycephalic phenotype and caudal vertebral anomalies.
    Title: Canine DVL2 variant contributes to brachycephalic phenotype and caudal vertebral anomalies.
  2. Analysis of the DVL2 variant protein showed that its ability to undergo WNT-induced phosphorylation is reduced, suggesting that altered WNT signaling may contribute to the Robinow-like syndrome in the screwtail breeds.
    Title: Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2
Names
dishevelled, dsh homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    32299943..32307523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038665359.1 → XP_038521287.1  segment polarity protein dishevelled homolog DVL-2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:260 → 347
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:419 → 502
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 258
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:510 → 721
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_038665357.1 → XP_038521285.1  segment polarity protein dishevelled homolog DVL-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:263 → 350
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:422 → 505
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 261
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:513 → 724
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  3. XM_038665355.1 → XP_038521283.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_038665356.1 → XP_038521284.1  segment polarity protein dishevelled homolog DVL-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  5. XM_038665354.1 → XP_038521282.1  segment polarity protein dishevelled homolog DVL-2 isoform X7

    UniProtKB/TrEMBL
    A0A8C0KC02, A0A8C0Q697, A0A8I3S1H6
    Related
    ENSCAFP00845027686.1, ENSCAFT00845035368.1
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265 → 352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424 → 507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515 → 726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  6. XM_038665358.1 → XP_038521286.1  segment polarity protein dishevelled homolog DVL-2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261 → 348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420 → 503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511 → 722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  7. XM_038665361.1 → XP_038521289.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0KDV3
    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  8. XM_038665360.1 → XP_038521288.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0KDV3
    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    32265249..32272821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038475466.1 → XP_038331394.1  segment polarity protein dishevelled homolog DVL-2 isoform X5

    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:260 → 347
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:419 → 502
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 258
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:510 → 721
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_038475463.1 → XP_038331391.1  segment polarity protein dishevelled homolog DVL-2 isoform X3

    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:263 → 350
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:422 → 505
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 261
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:513 → 724
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  3. XM_038475461.1 → XP_038331389.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_038475462.1 → XP_038331390.1  segment polarity protein dishevelled homolog DVL-2 isoform X2

    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  5. XM_038475460.1 → XP_038331388.1  segment polarity protein dishevelled homolog DVL-2 isoform X7

    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265 → 352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424 → 507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515 → 726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  6. XM_038475464.1 → XP_038331392.1  segment polarity protein dishevelled homolog DVL-2 isoform X4

    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261 → 348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420 → 503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511 → 722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  7. XM_038475468.1 → XP_038331396.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  8. XM_038475467.1 → XP_038331395.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    32224284..32231849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038600819.1 → XP_038456747.1  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 isoform X7

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    32401214..32408791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038536634.1 → XP_038392562.1  segment polarity protein dishevelled homolog DVL-2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:260 → 347
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:419 → 502
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 258
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:510 → 721
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_038536632.1 → XP_038392560.1  segment polarity protein dishevelled homolog DVL-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:263 → 350
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:422 → 505
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 261
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:513 → 724
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  3. XM_038536629.1 → XP_038392557.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_038536631.1 → XP_038392559.1  segment polarity protein dishevelled homolog DVL-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  5. XM_038536628.1 → XP_038392556.1  segment polarity protein dishevelled homolog DVL-2 isoform X7

    UniProtKB/TrEMBL
    A0A8C0KC02, A0A8C0Q697, A0A8I3S1H6
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265 → 352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424 → 507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515 → 726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  6. XM_038536633.1 → XP_038392561.1  segment polarity protein dishevelled homolog DVL-2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261 → 348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420 → 503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511 → 722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  7. XM_038536636.1 → XP_038392564.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0KDV3
    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  8. XM_038536635.1 → XP_038392563.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0KDV3
    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32332631..32340205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014113517.3 → XP_013968992.1  segment polarity protein dishevelled homolog DVL-2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:260 → 347
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:419 → 502
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 258
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:510 → 721
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_022418480.2 → XP_022274188.1  segment polarity protein dishevelled homolog DVL-2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:263 → 350
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:422 → 505
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 261
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:513 → 724
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  3. XM_014113515.3 → XP_013968990.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_014113516.3 → XP_013968991.1  segment polarity protein dishevelled homolog DVL-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:264 → 351
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:423 → 506
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 262
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:514 → 725
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  5. XM_546582.7 → XP_546582.2  segment polarity protein dishevelled homolog DVL-2 isoform X7

    UniProtKB/TrEMBL
    A0A8C0KC02, A0A8C0Q697, A0A8I3S1H6
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265 → 352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424 → 507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515 → 726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  6. XM_005619960.4 → XP_005620017.1  segment polarity protein dishevelled homolog DVL-2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KC02
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261 → 348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420 → 503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:125 → 259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511 → 722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  7. XM_038514716.1 → XP_038370644.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0KDV3
    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  8. XM_022418481.2 → XP_022274189.1  segment polarity protein dishevelled homolog DVL-2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0KDV3
    Conserved Domains (4) summary
    cd00992
    Location:167 → 254
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:326 → 409
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:27 → 165
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:417 → 628
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
Nucleotide Protein
Heading Accession and Version

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