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MMP1 matrix metallopeptidase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 489428, updated on 5-Mar-2024

Summary

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Official Symbol
MMP1provided by VGNC
Official Full Name
matrix metallopeptidase 1provided by VGNC
Primary source
VGNC:VGNC:43273
See related
Ensembl:ENSCAFG00845000871
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human all
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Genomic context

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Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (29029643..29038059)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (28926897..28935120)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (29119065..29127510)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (29064653..29073076)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (28944064..28952288)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 12 Neighboring gene matrix metallopeptidase 3 (stromelysin 1, progelatinase) Neighboring gene stromelysin-1-like Neighboring gene interstitial collagenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis. Gopal SK, et al. Sci Rep, 2016 Jun 21. PMID 27324842, Free PMC Article
  2. Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines. Docampo MJ, et al. Am J Vet Res, 2011 Aug. PMID 21801067
  3. Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression. Ray A, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16380175

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MMP1 silencing diminishes cell migration, invasion and anchorage-independent growth.
    Title: Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis.
  2. MMP-9 was overexpressed in malignant melanomas, compared with expression in melanocytomas, whereas no significant differences in MMP-2 and MT1-MMP immunostaining were detected.
    Title: Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
  3. results show that induction and activation of AP-1 and SAF-1 transcription factors are involved in the regulation of MMP-1 expression in the chondrocytes
    Title: Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interstitial collagenase
Names
matrix metallopeptidase 1 (interstitial collagenase)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    29029643..29038059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038665090.1 → XP_038521018.1  interstitial collagenase

    UniProtKB/TrEMBL
    A0A8C0T869, A0A8I3RPH1, A0A8P0ST47
    Related
    ENSCAFP00845001156.1, ENSCAFT00845001475.1
    Conserved Domains (3) summary
    cd00094
    Location:274 → 465
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:108 → 260
    Peptidase_M10; Matrixin
    pfam01471
    Location:27 → 87
    PG_binding_1; Putative peptidoglycan binding domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    29064653..29073076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038475211.1 → XP_038331139.1  interstitial collagenase

    Conserved Domains (3) summary
    cd00094
    Location:274 → 465
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:108 → 260
    Peptidase_M10; Matrixin
    pfam01471
    Location:27 → 87
    PG_binding_1; Putative peptidoglycan binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    28944064..28952288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038600558.1 → XP_038456486.1  interstitial collagenase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    29119065..29127510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038536352.1 → XP_038392280.1  interstitial collagenase

    UniProtKB/TrEMBL
    A0A8C0T869, A0A8I3RPH1, A0A8P0ST47
    Conserved Domains (3) summary
    cd00094
    Location:274 → 465
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:108 → 260
    Peptidase_M10; Matrixin
    pfam01471
    Location:27 → 87
    PG_binding_1; Putative peptidoglycan binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    28926897..28935120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_546546.7 → XP_546546.5  interstitial collagenase

    UniProtKB/TrEMBL
    A0A8C0T869, A0A8I3RPH1, A0A8P0ST47
    Conserved Domains (3) summary
    cd00094
    Location:274 → 465
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:108 → 260
    Peptidase_M10; Matrixin
    pfam01471
    Location:27 → 87
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein
Heading Accession and Version

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