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ITGA2 integrin subunit alpha 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489208, updated on 5-Mar-2024

Summary

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Official Symbol
ITGA2provided by VGNC
Official Full Name
integrin subunit alpha 2provided by VGNC
Primary source
VGNC:VGNC:42123
See related
Ensembl:ENSCAFG00845000432
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (62664801..62766959, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (61941741..62043869, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (63091317..63193515, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (62440055..62542152, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (62564620..62666770, complement)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene myocilin opposite strand protein-like Neighboring gene molybdenum cofactor synthesis 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene 60S ribosomal protein L36a-like Neighboring gene integrin subunit alpha 1 Neighboring gene pelota mRNA surveillance and ribosome rescue factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Kong T, et al. Mol Biol Cell, 2009 Nov. PMID 19776354, Free PMC Article
  2. Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV. Friedrichs J, et al. J Biol Chem, 2008 Nov 21. PMID 18806266
  3. A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Wang CZ, et al. Mol Biol Cell, 2006 Jun. PMID 16611743, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data demonstrate that G alpha 12 inhibits interaction of MDCK cells with collagen-I, the major ligand for alpha2 beta1 integrin, and regulates epithelial cell spreading and migration necessary for normal tubulogenesis.
    Title: G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis.
  2. galectin-3 influences integrin alpha(2)beta(1)-mediated adhesion complex formation by altering receptor clustering
    Title: Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    62664801..62766959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663725.1 → XP_038519653.1  integrin alpha-2

    UniProtKB/TrEMBL
    A0A8C0LX24, A0A8C0S0G4, A0A8I3MC22
    Related
    ENSCAFP00845000505.1, ENSCAFT00845000697.1
    Conserved Domains (3) summary
    smart00191
    Location:549 → 602
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:647 → 1058
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:171 → 351
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    62440055..62542152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038474023.1 → XP_038329951.1  integrin alpha-2

    Conserved Domains (3) summary
    smart00191
    Location:549 → 602
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:647 → 1058
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:171 → 351
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    62564620..62666770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038599416.1 → XP_038455344.1  integrin alpha-2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    63091317..63193515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038535122.1 → XP_038391050.1  integrin alpha-2

    UniProtKB/TrEMBL
    A0A8C0LX24, A0A8C0S0G4, A0A8I3MC22
    Conserved Domains (3) summary
    smart00191
    Location:549 → 602
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:647 → 1058
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:171 → 351
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    61941741..62043869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005619334.4 → XP_005619391.1  integrin alpha-2

    UniProtKB/TrEMBL
    A0A8C0LX24, A0A8C0S0G4, A0A8I3MC22
    Conserved Domains (3) summary
    smart00191
    Location:549 → 602
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:647 → 1058
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:171 → 351
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version

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