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F12 coagulation factor XII [ Canis lupus familiaris (dog) ]

Gene ID: 489090, updated on 5-Mar-2024

Summary

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Gene symbol
F12
Gene description
coagulation factor XII
See related
Ensembl:ENSCAFG00845010344
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (36316872..36334363)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (35918068..35935563)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (36837547..36855039)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (36142096..36159589)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (36328310..36345800)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene proline rich 7, synaptic Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene uncharacterized LOC111095525 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3 Neighboring gene regulator of G protein signaling 14 Neighboring gene lectin, mannose binding 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor XII
XP_038329496.1
XP_038390569.1
XP_038454873.1
XP_038519176.1
XP_546206.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    36316872..36334363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663248.1 → XP_038519176.1  coagulation factor XII

    UniProtKB/TrEMBL
    A0A8C0SPV7, A0A8I3NR05
    Related
    ENSCAFP00845014210.1, ENSCAFT00845018220.1
    Conserved Domains (6) summary
    smart00059
    Location:41 → 88
    FN2; Fibronectin type 2 domain
    cd00054
    Location:96 → 131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:133 → 171
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:365 → 608
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:178 → 208
    EGF; EGF-like domain
    cl00100
    Location:217 → 295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RNA

  1. XR_005425735.1 RNA Sequence

  2. XR_005425734.1 RNA Sequence

  3. XR_005425736.1 RNA Sequence

  4. XR_005425737.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    36142096..36159589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038473568.1 → XP_038329496.1  coagulation factor XII

    Conserved Domains (6) summary
    smart00059
    Location:41 → 88
    FN2; Fibronectin type 2 domain
    cd00054
    Location:96 → 131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:133 → 171
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:365 → 608
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:178 → 208
    EGF; EGF-like domain
    cl00100
    Location:217 → 295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RNA

  1. XR_005324335.1 RNA Sequence

  2. XR_005324334.1 RNA Sequence

  3. XR_005324336.1 RNA Sequence

  4. XR_005324337.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    36328310..36345800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038598945.1 → XP_038454873.1  coagulation factor XII

RNA

  1. XR_005392621.1 RNA Sequence

  2. XR_005392620.1 RNA Sequence

  3. XR_005392622.1 RNA Sequence

  4. XR_005392623.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    36837547..36855039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038534641.1 → XP_038390569.1  coagulation factor XII

    UniProtKB/TrEMBL
    A0A8C0SPV7, A0A8I3NR05
    Conserved Domains (6) summary
    smart00059
    Location:41 → 88
    FN2; Fibronectin type 2 domain
    cd00054
    Location:96 → 131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:133 → 171
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:365 → 608
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:178 → 208
    EGF; EGF-like domain
    cl00100
    Location:217 → 295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RNA

  1. XR_005358111.1 RNA Sequence

  2. XR_005358110.1 RNA Sequence

  3. XR_005358112.1 RNA Sequence

  4. XR_005358113.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35918068..35935563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_546206.5 → XP_546206.3  coagulation factor XII

    UniProtKB/TrEMBL
    A0A8C0SPV7, A0A8P0SKJ6
    Conserved Domains (6) summary
    smart00059
    Location:41 → 88
    FN2; Fibronectin type 2 domain
    cd00054
    Location:96 → 131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:133 → 171
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:365 → 608
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:178 → 208
    EGF; EGF-like domain
    cl00100
    Location:217 → 295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RNA

  1. XR_005335287.1 RNA Sequence

  2. XR_005335285.1 RNA Sequence

  3. XR_005335288.1 RNA Sequence

  4. XR_005335290.1 RNA Sequence

Nucleotide Protein
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