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PDE8B phosphodiesterase 8B [ Canis lupus familiaris (dog) ]

Gene ID: 488939, updated on 5-Mar-2024

Summary

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Official Symbol
PDE8Bprovided by VGNC
Official Full Name
phosphodiesterase 8Bprovided by VGNC
Primary source
VGNC:VGNC:44366
See related
Ensembl:ENSCAFG00845009245
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PDE8B in Genome Data Viewer
Location:
chromosome: 3
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (29211247..29477045, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (30529732..30795035, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (29457265..29761295, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (29145547..29411320, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (29126263..29366339, complement)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene orthopedia homeobox Neighboring gene WD repeat domain 41 Neighboring gene uncharacterized LOC102153760 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene uncharacterized LOC119871176 Neighboring gene uncharacterized LOC102154163 Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene small nucleolar RNA SNORA47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; LOW QUALITY PROTEIN: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
XP_038327494.1
XP_038327495.1
XP_038327496.1
XP_038327497.1
XP_038327498.1
XP_038327499.1
XP_038327793.1
XP_038327802.1
XP_038327810.1
XP_038327817.1
XP_038327826.1
XP_038327829.1
XP_038327837.1
XP_038388423.1
XP_038388424.1
XP_038388425.1
XP_038388426.1
XP_038388427.1
XP_038388428.1
XP_038388429.1
XP_038388430.1
XP_038388431.1
XP_038452710.1
XP_038516917.1
XP_038516918.1
XP_038516919.1
XP_038516920.1
XP_038516921.1
XP_038516922.1
XP_038516923.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    29211247..29477045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038660995.1 → XP_038516923.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    UniProtKB/TrEMBL
    A0A8C0R8A6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  2. XM_038660993.1 → XP_038516921.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

    UniProtKB/TrEMBL
    A0A8C0LQZ2
    Conserved Domains (3) summary
    COG2202
    Location:47 → 277
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513 → 760
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179 → 276
    PAS_9; PAS domain

  3. XM_038660994.1 → XP_038516922.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

    UniProtKB/TrEMBL
    A0A8C0LQZ2
    Related
    ENSCAFP00845012958.1, ENSCAFT00845016651.1
    Conserved Domains (3) summary
    COG2202
    Location:46 → 276
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:512 → 759
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:178 → 275
    PAS_9; PAS domain

  4. XM_038660990.1 → XP_038516918.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

    UniProtKB/TrEMBL
    A0A8C0RJ28
    Conserved Domains (4) summary
    COG2202
    Location:160 → 387
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:626 → 873
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:292 → 389
    PAS_9; PAS domain

  5. XM_038660991.1 → XP_038516919.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

    UniProtKB/TrEMBL
    A0A8C0N434, A0A8I3NCP0
    Related
    ENSCAFP00845013188.1, ENSCAFT00845016941.1
    Conserved Domains (4) summary
    COG2202
    Location:161 → 330
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:577 → 824
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:293 → 346
    PAS_9; PAS domain

  6. XM_038660992.1 → XP_038516920.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

    UniProtKB/TrEMBL
    A0A8C0RJ28
    Conserved Domains (4) summary
    COG2202
    Location:161 → 388
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:627 → 819
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:293 → 390
    PAS_9; PAS domain

  7. XM_038660989.1 → XP_038516917.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

    UniProtKB/TrEMBL
    A0A8C0RJ28, A0A8I3NCG5
    Related
    ENSCAFP00845013275.1, ENSCAFT00845017040.1
    Conserved Domains (4) summary
    COG2202
    Location:161 → 388
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:627 → 874
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:293 → 390
    PAS_9; PAS domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    29145547..29411320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471570.1 → XP_038327498.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  2. XM_038471571.1 → XP_038327499.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

  3. XM_038471566.1 → XP_038327494.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

    Conserved Domains (3) summary
    COG2202
    Location:47 → 277
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513 → 760
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179 → 276
    PAS_9; PAS domain

  4. XM_038471567.1 → XP_038327495.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

    Conserved Domains (3) summary
    COG2202
    Location:46 → 276
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:512 → 759
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:178 → 275
    PAS_9; PAS domain

  5. XM_038471569.1 → XP_038327497.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  6. XM_038471568.1 → XP_038327496.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    29126263..29366339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596782.1 → XP_038452710.1  LOW QUALITY PROTEIN: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    29457265..29761295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532501.1 → XP_038388429.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    UniProtKB/TrEMBL
    A0A8C0R8A6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  2. XM_038532499.1 → XP_038388427.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

    UniProtKB/TrEMBL
    A0A8C0LQZ2
    Conserved Domains (3) summary
    COG2202
    Location:47 → 277
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513 → 760
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179 → 276
    PAS_9; PAS domain

  3. XM_038532500.1 → XP_038388428.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

    UniProtKB/TrEMBL
    A0A8C0LQZ2
    Conserved Domains (3) summary
    COG2202
    Location:46 → 276
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:512 → 759
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:178 → 275
    PAS_9; PAS domain

  4. XM_038532496.1 → XP_038388424.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X10

    UniProtKB/TrEMBL
    A0A8C0RJ28
    Conserved Domains (4) summary
    COG2202
    Location:158 → 385
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:624 → 871
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:290 → 387
    PAS_9; PAS domain

  5. XM_038532497.1 → XP_038388425.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

    UniProtKB/TrEMBL
    A0A8C0N434, A0A8I3NCP0, A0A8P0PHQ9
    Conserved Domains (4) summary
    COG2202
    Location:159 → 328
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:575 → 822
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:291 → 344
    PAS_9; PAS domain

  6. XM_038532498.1 → XP_038388426.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X12

    UniProtKB/TrEMBL
    A0A8C0RJ28, A0A8P0SED1
    Conserved Domains (4) summary
    COG2202
    Location:159 → 386
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:625 → 817
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:291 → 388
    PAS_9; PAS domain

  7. XM_038532495.1 → XP_038388423.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X9

    UniProtKB/TrEMBL
    A0A8C0RJ28, A0A8P0PGU8
    Conserved Domains (4) summary
    COG2202
    Location:159 → 386
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:625 → 872
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:291 → 388
    PAS_9; PAS domain

  8. XM_038532503.1 → XP_038388431.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    UniProtKB/TrEMBL
    A0A8C0R8A6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  9. XM_038532502.1 → XP_038388430.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    UniProtKB/TrEMBL
    A0A8C0R8A6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30529732..30795035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471909.1 → XP_038327837.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    UniProtKB/TrEMBL
    A0A8C0R8A6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  2. XM_038471898.1 → XP_038327826.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

    UniProtKB/TrEMBL
    A0A8C0LQZ2
    Conserved Domains (3) summary
    COG2202
    Location:47 → 277
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513 → 760
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179 → 276
    PAS_9; PAS domain

  3. XM_038471901.1 → XP_038327829.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

    UniProtKB/TrEMBL
    A0A8C0LQZ2
    Conserved Domains (3) summary
    COG2202
    Location:46 → 276
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:512 → 759
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:178 → 275
    PAS_9; PAS domain

  4. XM_038471874.1 → XP_038327802.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

    UniProtKB/TrEMBL
    A0A8C0RJ28
    Conserved Domains (4) summary
    COG2202
    Location:158 → 385
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:624 → 871
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:290 → 387
    PAS_9; PAS domain

  5. XM_038471882.1 → XP_038327810.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

    UniProtKB/TrEMBL
    A0A8C0N434, A0A8I3NCP0, A0A8P0PHQ9
    Conserved Domains (4) summary
    COG2202
    Location:159 → 328
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:575 → 822
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:291 → 344
    PAS_9; PAS domain

  6. XM_038471889.1 → XP_038327817.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

    UniProtKB/TrEMBL
    A0A8C0RJ28, A0A8P0SED1
    Conserved Domains (4) summary
    COG2202
    Location:159 → 386
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:625 → 817
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:291 → 388
    PAS_9; PAS domain

  7. XM_038471865.1 → XP_038327793.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

    UniProtKB/TrEMBL
    A0A8C0RJ28, A0A8P0PGU8
    Conserved Domains (4) summary
    COG2202
    Location:159 → 386
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:625 → 872
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:291 → 388
    PAS_9; PAS domain
Nucleotide Protein
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