NCSTN nicastrin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NCSTNprovided by VGNC
Official Full Name: nicastrinprovided by VGNC
Primary source: VGNC:VGNC:43668
See related: Ensembl:ENSCAFG00845030514
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 38

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	38	NC_051842.1 (21994646..22009338, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	38	NC_006620.4 (21951865..21966592, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	38	NC_049259.1 (22705808..22720574, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	38	NC_049298.1 (21899466..21914196, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	38	NC_049779.1 (22295995..22310753, complement)

Chromosome 38 - NC_051842.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein processing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nicastrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313840.1 → NP_001300769.1 nicastrin precursor

Status: PROVISIONAL

Source sequence(s)

AB793319

UniProtKB/TrEMBL

A0A8C0SS49, A0A8C0STX4, M1VPL1

Related

ENSCAFP00845042573.1, ENSCAFT00845054189.1

Conserved Domains (1) summary

cd03881
Location:175 → 482

M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex