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NPY1R neuropeptide Y receptor Y1 [ Homo sapiens (human) ]

Gene ID: 4886, updated on 5-Mar-2024

Summary

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Official Symbol
NPY1Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y1provided by HGNC
Primary source
HGNC:HGNC:7956
See related
Ensembl:ENSG00000164128 MIM:162641; AllianceGenome:HGNC:7956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPYR; NPY1-R
Summary
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Expression
Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues See more
Orthologs
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Genomic context

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See NPY1R in Genome Data Viewer
Location:
4q32.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (163323962..163344689, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (166671793..166692717, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164245114..164253748, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75696 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:164238175-164238759 Neighboring gene neuropeptide Y receptor Y5 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:164336685-164337439 Neighboring gene transketolase like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer. Bhat R, et al. Sci Rep, 2022 Feb 4. PMID 35121782, Free PMC Article
  2. Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt. Dawoud MM, et al. Appl Immunohistochem Mol Morphol, 2021 Apr 1. PMID 33086223
  3. Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer. Desai D, et al. Curr Protein Pept Sci, 2020. PMID 32951575
  4. Structural basis of ligand binding modes at the neuropeptide Y Y(1) receptor. Yang Z, et al. Nature, 2018 Apr. PMID 29670288, Free PMC Article
  5. Neuropeptide Y1 receptor inhibits cell growth through inactivating mitogen-activated protein kinase signal pathway in human hepatocellular carcinoma. Lv X, et al. Med Oncol, 2016 Jul. PMID 27262566

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity.
    Title: Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity.
  2. Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
    Title: Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
  3. NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer.
    Title: NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer.
  4. Structural basis of neuropeptide Y signaling through Y1 receptor.
    Title: Structural basis of neuropeptide Y signaling through Y1 receptor.
  5. Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
    Title: Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
  6. Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
    Title: Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
  7. Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt.
    Title: Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt.
  8. Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
    Title: Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
  9. Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer.
    Title: Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer.
  10. the current review aims to compile, evaluate and summarise current knowledge on PYY, with particular emphasis on obesity and diabetes treatment, and the importance of specific Y receptor interactions for this.
    Title: Emerging therapeutic potential for peptide YY for obesity-diabetes.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pancreatic polypeptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
neuropeptide Y receptor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000909.6 → NP_000900.1  neuropeptide Y receptor type 1

    See identical proteins and their annotated locations for NP_000900.1

    Status: VALIDATED

    Source sequence(s)
    AC079238, BC036657
    Consensus CDS
    CCDS34089.1
    UniProtKB/Swiss-Prot
    B2R6H5, P25929
    Related
    ENSP00000354652.2, ENST00000296533.3
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:52 → 176
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    163323962..163344689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263031.5 → XP_005263088.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005263088.1

    UniProtKB/Swiss-Prot
    B2R6H5, P25929
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:52 → 176
    7tm_4; Olfactory receptor

  2. XM_011532010.4 → XP_011530312.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011530312.1

    UniProtKB/Swiss-Prot
    B2R6H5, P25929
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:52 → 176
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    166671793..166692717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350119.1 → XP_054206094.1  neuropeptide Y receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R6H5, P25929

  2. XM_054350120.1 → XP_054206095.1  neuropeptide Y receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R6H5, P25929
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25929.1 GenPept UniProtKB/Swiss-Prot:P25929

Gene LinkOut

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