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ITGAV integrin subunit alpha V [ Canis lupus familiaris (dog) ]

Gene ID: 488437, updated on 5-Mar-2024

Summary

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Official Symbol
ITGAVprovided by VGNC
Official Full Name
integrin subunit alpha Vprovided by VGNC
Primary source
VGNC:VGNC:42134
See related
Ensembl:ENSCAFG00845017805
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 36
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (29028662..29116151)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (28702231..28789503)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (29188373..29276043)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (29087085..29173016)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (29020979..29108231)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867858 Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene family with sequence similarity 171 member B Neighboring gene zinc finger SWIM-type containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. αV-integrins are required for mechanotransduction in MDCK epithelial cells. Teräväinen TP, et al. PLoS One, 2013. PMID 23977051, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alphaV-integrins regulate the maturation of focal adhesions (FAs) and cell spreading.
    Title: αV-integrins are required for mechanotransduction in MDCK epithelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-V
Names
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    29028662..29116151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446753.1 → XP_038302681.1  integrin alpha-V isoform X1

    UniProtKB/TrEMBL
    A0A8I3P4U9
    Related
    ENSCAFP00845024872.1, ENSCAFT00845031789.1
    Conserved Domains (4) summary
    smart00191
    Location:361 → 415
    Int_alpha; Integrin alpha (beta-propellor repeats)
    sd00039
    Location:120 → 177
    7WD40; WD40 repeat [structural motif]
    pfam08441
    Location:461 → 907
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:215 → 265
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    29087085..29173016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038521369.1 → XP_038377297.1  integrin alpha-V isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    29020979..29108231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649473.1 → XP_038505401.1  integrin alpha-V isoform X3

  2. XM_038649474.1 → XP_038505402.1  integrin alpha-V isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    29188373..29276043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038584523.1 → XP_038440451.1  integrin alpha-V isoform X1

    UniProtKB/TrEMBL
    A0A8C0S2C7, A0A8I3P4U9

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    28702231..28789503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038463276.1 → XP_038319204.1  integrin alpha-V isoform X5

    UniProtKB/TrEMBL
    A0A8C0S2C7, A0A8I3P4U9
    Conserved Domains (4) summary
    smart00191
    Location:369 → 423
    Int_alpha; Integrin alpha (beta-propellor repeats)
    sd00039
    Location:128 → 185
    7WD40; WD40 repeat [structural motif]
    pfam08441
    Location:469 → 915
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:223 → 273
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  2. XM_038463277.1 → XP_038319205.1  integrin alpha-V isoform X6

    UniProtKB/TrEMBL
    A0A8C0S2C7, A0A8I3P4U9
    Conserved Domains (4) summary
    smart00191
    Location:368 → 422
    Int_alpha; Integrin alpha (beta-propellor repeats)
    sd00039
    Location:127 → 184
    7WD40; WD40 repeat [structural motif]
    pfam08441
    Location:468 → 915
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:222 → 272
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Nucleotide Protein
Heading Accession and Version

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