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ITGA4 integrin subunit alpha 4 [ Canis lupus familiaris (dog) ]

Gene ID: 488429, updated on 5-Mar-2024

Summary

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Official Symbol
ITGA4provided by VGNC
Official Full Name
integrin subunit alpha 4provided by VGNC
Primary source
VGNC:VGNC:42126
See related
Ensembl:ENSCAFG00845027215
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 36
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (24815313..24895039)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (24675932..24755430)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (25004898..25084914)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (24904710..24984278)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (24869937..24949662)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(I) chain-like Neighboring gene ubiquitin conjugating enzyme E2 E3 Neighboring gene uncharacterized LOC119867798 Neighboring gene ceramide kinase like Neighboring gene peroxiredoxin-1-like Neighboring gene neuronal differentiation 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-4; LOW QUALITY PROTEIN: integrin alpha-4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    24815313..24895039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038447239.1 → XP_038303167.1  integrin alpha-4 isoform X3

    Conserved Domains (1) summary
    smart00191
    Location:305 → 354
    Int_alpha; Integrin alpha (beta-propellor repeats)

  2. XM_038447238.1 → XP_038303166.1  integrin alpha-4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MRI1, A0A8C0Z2Z2
    Conserved Domains (2) summary
    smart00191
    Location:368 → 420
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:465 → 901
    Integrin_alpha2; Integrin alpha

  3. XM_038447237.1 → XP_038303165.1  integrin alpha-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MRI1, A0A8C0Z2Z2, A0A8I3PRY8
    Related
    ENSCAFP00845037680.1, ENSCAFT00845048021.1
    Conserved Domains (2) summary
    smart00191
    Location:368 → 420
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:465 → 901
    Integrin_alpha2; Integrin alpha

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    24904710..24984278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038521314.1 → XP_038377242.1  LOW QUALITY PROTEIN: integrin alpha-4 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    24869937..24949662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649436.1 → XP_038505364.1  integrin alpha-4 isoform X3

    Conserved Domains (1) summary
    smart00191
    Location:305 → 354
    Int_alpha; Integrin alpha (beta-propellor repeats)

  2. XM_038649435.1 → XP_038505363.1  integrin alpha-4 isoform X2

  3. XM_038649434.1 → XP_038505362.1  integrin alpha-4 isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    25004898..25084914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038585022.1 → XP_038440950.1  integrin alpha-4 isoform X3

    Conserved Domains (1) summary
    smart00191
    Location:305 → 354
    Int_alpha; Integrin alpha (beta-propellor repeats)

  2. XM_038585021.1 → XP_038440949.1  integrin alpha-4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MRI1, A0A8C0Z2Z2

  3. XM_038585020.1 → XP_038440948.1  integrin alpha-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MRI1, A0A8C0Z2Z2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24675932..24755430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038463287.1 → XP_038319215.1  integrin alpha-4 isoform X3

    Conserved Domains (1) summary
    smart00191
    Location:305 → 354
    Int_alpha; Integrin alpha (beta-propellor repeats)

  2. XM_038463286.1 → XP_038319214.1  integrin alpha-4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MRI1
    Conserved Domains (2) summary
    smart00191
    Location:368 → 420
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:465 → 901
    Integrin_alpha2; Integrin alpha

  3. XM_038463285.1 → XP_038319213.1  integrin alpha-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MRI1, A0A8P0NFT9
    Conserved Domains (2) summary
    smart00191
    Location:368 → 420
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:465 → 901
    Integrin_alpha2; Integrin alpha
Nucleotide Protein
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