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SOX2 SRY-box transcription factor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 488092, updated on 5-Mar-2024

Summary

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Official Symbol
SOX2provided by VGNC
Official Full Name
SRY-box transcription factor 2provided by VGNC
Primary source
VGNC:VGNC:46678
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 34
Exon count:
1
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (14755806..14757946)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (18934171..18936303)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (15026650..15028779)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (14797347..14799478)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (14782119..14784242)

Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867493 Neighboring gene cilia- and flagella-associated protein 44-like Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 Neighboring gene uncharacterized LOC119867494 Neighboring gene ribosomal biogenesis factor-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. van Rijn SJ, et al. Vet J, 2015 Jun. PMID 25956343
  2. Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair. Erwin WM, et al. Spine (Phila Pa 1976), 2013 Feb 1. PMID 22772571

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We created canine induced pluripotent stem cells (ciPSCs) from adult fibroblasts using OKSM transduction. These cells, grown in FGF2 and LIF, exhibited endogenous pluripotency markers including SOX2, and differentiated into all germ layers, both in vitro and in vivo. This study highlights the unique aspects of canine epigenetic reprogramming and its similarity to embryonic stem cells in other mammalian species.
    Title: Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts.
  2. These results suggested that Pax7 and Sox2 remain interesting targets for molecular investigations into their role in pituitary tumorigenesis, but were unsuitable as clinical prognosticators in dogs.
    Title: Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas.
  3. Data indicate that intervertebral disc (IVD)-derived stem/progenitor cells express Oct3/4, Sox2, CD133 (PROM1), Nanog, and Nestin.
    Title: Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcription factor SOX-2
Names
SRY-box 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051838.1 Reference ROS_Cfam_1.0

    Range
    14755806..14757946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445642.1 → XP_038301570.1  transcription factor SOX-2

    UniProtKB/TrEMBL
    A0A8C0LI97
    Conserved Domains (2) summary
    cd01388
    Location:45 → 116
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam12336
    Location:115 → 205
    SOXp; SOX transcription factor

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049294.1 Alternate UMICH_Zoey_3.1

    Range
    14797347..14799478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519824.1 → XP_038375752.1  transcription factor SOX-2

    Conserved Domains (2) summary
    cd01388
    Location:45 → 116
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam12336
    Location:115 → 205
    SOXp; SOX transcription factor

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

    Range
    14782119..14784242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647875.1 → XP_038503803.1  transcription factor SOX-2

    Conserved Domains (2) summary
    cd01388
    Location:45 → 116
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam12336
    Location:115 → 205
    SOXp; SOX transcription factor

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

    Range
    15026650..15028779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583467.1 → XP_038439395.1  transcription factor SOX-2

    UniProtKB/TrEMBL
    A0A8C0LI97
    Conserved Domains (2) summary
    cd01388
    Location:45 → 116
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam12336
    Location:115 → 205
    SOXp; SOX transcription factor

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18934171..18936303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005639752.4 → XP_005639809.2  transcription factor SOX-2

    Conserved Domains (2) summary
    cd01388
    Location:46 → 117
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam12336
    Location:116 → 206
    SOXp; SOX transcription factor
Nucleotide Protein
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