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CASP6 caspase 6 [ Canis lupus familiaris (dog) ]

Gene ID: 487899, updated on 5-Mar-2024

Summary

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Official Symbol
CASP6provided by VGNC
Official Full Name
caspase 6provided by VGNC
Primary source
VGNC:VGNC:57400
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 32
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (30117004..30130146, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (12119155..12132295)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (9980365..9993491)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (30111494..30124567, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (29855989..29869067, complement)

Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene SEC24 homolog B, COPII coat complex component Neighboring gene uncharacterized LOC111093576 Neighboring gene mitochondrial calcium uniporter dominant negative subunit beta Neighboring gene uncharacterized LOC111093579 Neighboring gene U6 spliceosomal RNA Neighboring gene phospholipase A2 group XIIA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-6
XP_038300287.1
XP_038300288.1
XP_038317938.1
XP_038374674.1
XP_038374675.1
XP_038437846.1
XP_038437847.1
XP_038502621.1
XP_038502622.1
XP_545022.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051836.1 Reference ROS_Cfam_1.0

    Range
    30117004..30130146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038444359.1 → XP_038300287.1  caspase-6 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:101 → 353
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_038444360.1 → XP_038300288.1  caspase-6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KSE5, A0A8C0KT21, A0A8C0PDQ4
    Conserved Domains (1) summary
    smart00115
    Location:37 → 290
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049292.1 Alternate UMICH_Zoey_3.1

    Range
    30111494..30124567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518746.1 → XP_038374674.1  caspase-6 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:101 → 353
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_038518747.1 → XP_038374675.1  caspase-6 isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:37 → 290
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

    Range
    29855989..29869067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038646693.1 → XP_038502621.1  caspase-6 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:101 → 353
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_038646694.1 → XP_038502622.1  caspase-6 isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:37 → 290
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

    Range
    9980365..9993491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038581918.1 → XP_038437846.1  caspase-6 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:101 → 353
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_038581919.1 → XP_038437847.1  caspase-6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KSE5, A0A8C0KT21, A0A8C0PDQ4
    Conserved Domains (1) summary
    smart00115
    Location:37 → 290
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    12119155..12132295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038462010.1 → XP_038317938.1  caspase-6 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:101 → 353
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_545022.7 → XP_545022.4  caspase-6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KSE5, A0A8C0KT21, A0A8C0PDQ4
    Conserved Domains (1) summary
    smart00115
    Location:37 → 290
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
Nucleotide Protein
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