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APH1B aph-1 homolog B, gamma-secretase subunit [ Canis lupus familiaris (dog) ]

Gene ID: 487589, updated on 5-Mar-2024

Summary

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Official Symbol
APH1Bprovided by VGNC
Official Full Name
aph-1 homolog B, gamma-secretase subunitprovided by VGNC
Primary source
VGNC:VGNC:58291
See related
Ensembl:ENSCAFG00845020653
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 30
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (28025424..28059260)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (27772768..27806586)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (28268502..28298404)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (27962895..27996685)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (28024979..28058785)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866911 Neighboring gene uncharacterized LOC119866913 Neighboring gene RAB8B, member RAS oncogene family Neighboring gene uncharacterized LOC119866912 Neighboring gene carbonic anhydrase 12 Neighboring gene uncharacterized LOC106558069 Neighboring gene uncharacterized LOC111093411

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of gamma-secretase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gamma-secretase subunit APH-1B
Names
anterior pharynx defective 1 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    28025424..28059260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038442558.1 → XP_038298486.1  gamma-secretase subunit APH-1B

    UniProtKB/TrEMBL
    A0A8C0K6B9, A0A8C0P6Y9, A0A8C0PAY1, A0A8I3P5D1, A0A8I3PKP8
    Related
    ENSCAFP00845028505.1, ENSCAFT00845036419.1
    Conserved Domains (1) summary
    pfam06105
    Location:3 → 232
    Aph-1; Aph-1 protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    27962895..27996685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038517010.1 → XP_038372938.1  gamma-secretase subunit APH-1B

    Conserved Domains (1) summary
    pfam06105
    Location:3 → 232
    Aph-1; Aph-1 protein

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    28024979..28058785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644942.1 → XP_038500870.1  gamma-secretase subunit APH-1B

    Conserved Domains (1) summary
    pfam06105
    Location:3 → 232
    Aph-1; Aph-1 protein

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    28268502..28298404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580632.1 → XP_038436560.1  gamma-secretase subunit APH-1B

    UniProtKB/TrEMBL
    A0A8C0K6B9, A0A8C0P6Y9, A0A8C0PAY1, A0A8I3P5D1, A0A8I3PKP8
    Conserved Domains (1) summary
    pfam06105
    Location:3 → 232
    Aph-1; Aph-1 protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27772768..27806586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038461149.1 → XP_038317077.1  gamma-secretase subunit APH-1B

    UniProtKB/TrEMBL
    A0A8C0K6B9, A0A8C0P6Y9, A0A8C0PAY1, A0A8I3P5D1, A0A8I3PKP8
    Conserved Domains (1) summary
    pfam06105
    Location:3 → 232
    Aph-1; Aph-1 protein
Nucleotide Protein
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