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MMP15 matrix metallopeptidase 15 [ Canis lupus familiaris (dog) ]

Gene ID: 487257, updated on 5-Mar-2024

Summary

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Official Symbol
MMP15provided by VGNC
Official Full Name
matrix metallopeptidase 15provided by VGNC
Primary source
VGNC:VGNC:49926
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (59042165..59062706, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (55133201..55153695, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (57774141..57794621, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (55873315..55893796, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (56881102..56901624, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene casein kinase 2 alpha 2 Neighboring gene uncharacterized LOC102155801 Neighboring gene uncharacterized LOC106558013 Neighboring gene cilia and flagella associated protein 20 Neighboring gene uncharacterized LOC111092702 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1 Neighboring gene zinc finger protein 319

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
matrix metalloproteinase-15
XP_038316584.1
XP_038316588.1
XP_038326035.1
XP_038326036.1
XP_038386851.1
XP_038386852.1
XP_038451071.1
XP_038451072.1
XP_038515155.1
XP_038515156.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    59042165..59062706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659227.1 → XP_038515155.1  matrix metalloproteinase-15 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M207, A0A8C0QIW1, A0A8P0NAQ4
    Conserved Domains (4) summary
    cd00094
    Location:367 → 559
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:138 → 304
    Peptidase_M10; Matrixin
    pfam01471
    Location:52 → 106
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:608 → 678
    DUF3377; Domain of unknown function (DUF3377)

  2. XM_038659228.1 → XP_038515156.1  matrix metalloproteinase-15 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QXV0
    Conserved Domains (4) summary
    cd00094
    Location:364 → 556
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:135 → 301
    Peptidase_M10; Matrixin
    pfam01471
    Location:51 → 103
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:605 → 675
    DUF3377; Domain of unknown function (DUF3377)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    55873315..55893796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038470107.1 → XP_038326035.1  matrix metalloproteinase-15 isoform X1

    Conserved Domains (4) summary
    cd00094
    Location:367 → 559
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:138 → 304
    Peptidase_M10; Matrixin
    pfam01471
    Location:52 → 106
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:608 → 678
    DUF3377; Domain of unknown function (DUF3377)

  2. XM_038470108.1 → XP_038326036.1  matrix metalloproteinase-15 isoform X2

    Conserved Domains (4) summary
    cd00094
    Location:364 → 556
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:135 → 301
    Peptidase_M10; Matrixin
    pfam01471
    Location:51 → 103
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:605 → 675
    DUF3377; Domain of unknown function (DUF3377)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    56881102..56901624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038595143.1 → XP_038451071.1  matrix metalloproteinase-15 isoform X1

    Conserved Domains (4) summary
    cd00094
    Location:367 → 559
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:138 → 304
    Peptidase_M10; Matrixin
    pfam01471
    Location:52 → 106
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:608 → 678
    DUF3377; Domain of unknown function (DUF3377)

  2. XM_038595144.1 → XP_038451072.1  matrix metalloproteinase-15 isoform X2

    Conserved Domains (4) summary
    cd00094
    Location:364 → 556
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:135 → 301
    Peptidase_M10; Matrixin
    pfam01471
    Location:51 → 103
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:605 → 675
    DUF3377; Domain of unknown function (DUF3377)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    57774141..57794621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038530923.1 → XP_038386851.1  matrix metalloproteinase-15 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M207, A0A8C0QIW1, A0A8P0NAQ4
    Conserved Domains (4) summary
    cd00094
    Location:367 → 559
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:138 → 304
    Peptidase_M10; Matrixin
    pfam01471
    Location:52 → 106
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:608 → 678
    DUF3377; Domain of unknown function (DUF3377)

  2. XM_038530924.1 → XP_038386852.1  matrix metalloproteinase-15 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QXV0
    Conserved Domains (4) summary
    cd00094
    Location:364 → 556
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:135 → 301
    Peptidase_M10; Matrixin
    pfam01471
    Location:51 → 103
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:605 → 675
    DUF3377; Domain of unknown function (DUF3377)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    55133201..55153695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038460656.1 → XP_038316584.1  matrix metalloproteinase-15 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M207, A0A8C0QIW1, A0A8P0NAQ4
    Conserved Domains (4) summary
    cd00094
    Location:367 → 559
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:138 → 304
    Peptidase_M10; Matrixin
    pfam01471
    Location:52 → 106
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:608 → 678
    DUF3377; Domain of unknown function (DUF3377)

  2. XM_038460660.1 → XP_038316588.1  matrix metalloproteinase-15 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QXV0
    Conserved Domains (4) summary
    cd00094
    Location:364 → 556
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:135 → 301
    Peptidase_M10; Matrixin
    pfam01471
    Location:51 → 103
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:605 → 675
    DUF3377; Domain of unknown function (DUF3377)
Nucleotide Protein
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