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PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Canis lupus familiaris (dog) ]

Gene ID: 487235, updated on 5-Mar-2024

Summary

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Official Symbol
PIK3R1provided by VGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 1provided by VGNC
Primary source
VGNC:VGNC:44560
See related
Ensembl:ENSCAFG00845011717
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (53951256..54032010)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (50408936..50489628)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (52678736..52759442)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (51011708..51092420)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (51791194..51871863)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870276 Neighboring gene uncharacterized LOC111092497 Neighboring gene uncharacterized LOC111092498 Neighboring gene uncharacterized LOC111092499 Neighboring gene uncharacterized LOC119870277

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells. Barwe SP, et al. Cell Mol Biol (Noisy-le-grand), 2006 Dec 30. PMID 17535735
  2. Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Megquier K, et al. Mol Cancer Res, 2019 Dec. PMID 31570656, Free PMC Article
  3. Comparison of insulin signaling gene expression in insulin sensitive tissues between cats and dogs. Mori A, et al. Vet Res Commun, 2009 Mar. PMID 19043794

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and RNA sequencing (74 hemangiosarcomas from multiple breeds). Somatic coding mutations occurred most frequently in the tumor suppressor TP53 (59.6% of cases) as well as two genes in the PI3K pathway: the oncogene PIK3CA (29.8%) and its regulatory subunit PIK3R1 (8.5%).
    Title: Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.
  2. PKC is involved upstream of PI3-Kinase in the suppression of Na,K-Beta mediated cell motility in carcinoma cells.(Na,K-Beta1)
    Title: Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha
Names
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    53951256..54032010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659060.1 → XP_038514988.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  2. XM_038659062.1 → XP_038514990.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  3. XM_038659061.1 → XP_038514989.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  4. XM_038659064.1 → XP_038514992.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  5. XM_038659063.1 → XP_038514991.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Related
    ENSCAFP00845016363.1, ENSCAFT00845020842.1
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  6. XM_038659066.1 → XP_038514994.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0M2S6, A0A8I3NJ30, A0A8P0NVD8
    Related
    ENSCAFP00845016412.1, ENSCAFT00845020896.1
    Conserved Domains (3) summary
    cd09930
    Location:317 → 420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:25 → 135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140 → 300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  7. XM_038659065.1 → XP_038514993.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0M2S6, A0A8C0PYF3, A0A8I3NK93
    Related
    ENSCAFP00845016464.1, ENSCAFT00845020954.1
    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    51011708..51092420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038469953.1 → XP_038325881.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  2. XM_038469955.1 → XP_038325883.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  3. XM_038469954.1 → XP_038325882.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  4. XM_038469957.1 → XP_038325885.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  5. XM_038469956.1 → XP_038325884.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  6. XM_038469959.1 → XP_038325887.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    Conserved Domains (3) summary
    cd09930
    Location:317 → 420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:25 → 135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140 → 300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  7. XM_038469958.1 → XP_038325886.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    51791194..51871863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038594986.1 → XP_038450914.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  2. XM_038594988.1 → XP_038450916.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  3. XM_038594987.1 → XP_038450915.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  4. XM_038594990.1 → XP_038450918.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  5. XM_038594989.1 → XP_038450917.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  6. XM_038594991.1 → XP_038450919.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    52678736..52759442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038530761.1 → XP_038386689.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  2. XM_038530764.1 → XP_038386692.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  3. XM_038530763.1 → XP_038386691.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  4. XM_038530766.1 → XP_038386694.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  5. XM_038530765.1 → XP_038386693.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  6. XM_038530768.1 → XP_038386696.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0M2S6, A0A8I3NJ30, A0A8P0NVD8
    Conserved Domains (3) summary
    cd09930
    Location:317 → 420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:25 → 135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140 → 300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  7. XM_038530767.1 → XP_038386695.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0M2S6, A0A8C0PYF3, A0A8I3NK93
    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    50408936..50489628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038459835.1 → XP_038315763.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  2. XM_038459839.1 → XP_038315767.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  3. XM_014108822.3 → XP_013964297.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  4. XM_014108824.3 → XP_013964299.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  5. XM_022410134.2 → XP_022265842.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0M2N8, A0A8C0M840, A0A8C0R439, A0A8I3N971
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  6. XM_003433815.5 → XP_003433863.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_003433863.1

    UniProtKB/TrEMBL
    A0A8C0M2S6, A0A8I3NJ30, A0A8P0NVD8
    Conserved Domains (3) summary
    cd09930
    Location:317 → 420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:25 → 135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140 → 300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  7. XM_544363.7 → XP_544363.2  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    See identical proteins and their annotated locations for XP_544363.2

    UniProtKB/TrEMBL
    A0A8C0M2S6, A0A8C0PYF3, A0A8I3NK93
    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
Nucleotide Protein
Heading Accession and Version

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