MMP16 matrix metallopeptidase 16 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MMP16provided by VGNC
Official Full Name: matrix metallopeptidase 16provided by VGNC
Primary source: VGNC:VGNC:43278
See related: Ensembl:ENSCAFG00845018720
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	29	NC_051833.1 (34093268..34403773, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	29	NC_006611.4 (34056176..34360687, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	29	NC_049250.1 (34536488..34840936, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	29	NC_049289.1 (34106198..34398221, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	29	NC_049770.1 (34114566..34418869, complement)

Chromosome 29 - NC_051833.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

AB021228 (e-PCR)
- UniSTS:163337

BAC_382-E23 (e-PCR)
- UniSTS:262641

MMP16_920 (e-PCR)
- UniSTS:277491

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: matrix metalloproteinase-16; LOW QUALITY PROTEIN: matrix metalloproteinase-16

XP_022268176.1

EC 3.4.24.-

XP_038297486.1

EC 3.4.24.-

XP_038297487.1

EC 3.4.24.-

XP_038372056.1

EC 3.4.24.-

XP_038435628.1

EC 3.4.24.-

XP_038435629.1

EC 3.4.24.-

XP_038499867.1

EC 3.4.24.-

XP_038499868.1

EC 3.4.24.-

XP_544165.3

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051833.1 Reference ROS_Cfam_1.0

Range

34093268..34403773 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038441559.1 → XP_038297487.1 matrix metalloproteinase-16 isoform X2

UniProtKB/TrEMBL

A0A8C0T0T4

Conserved Domains (4) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 499

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain
XM_038441558.1 → XP_038297486.1 matrix metalloproteinase-16 isoform X1

UniProtKB/TrEMBL

A0A8C0KH15, A0A8C0PE40, A0A8C0T0T4, A0A8I3S0N4

Related

ENSCAFP00845025899.1, ENSCAFT00845033087.1

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)

Alternate UMICH_Zoey_3.1

Genomic

NC_049289.1 Alternate UMICH_Zoey_3.1

Range

34106198..34398221 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038516128.1 → XP_038372056.1 LOW QUALITY PROTEIN: matrix metalloproteinase-16 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049770.1 Alternate UNSW_CanFamBas_1.0

Range

34114566..34418869 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038643940.1 → XP_038499868.1 matrix metalloproteinase-16 isoform X2

Conserved Domains (4) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 499

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain
XM_038643939.1 → XP_038499867.1 matrix metalloproteinase-16 isoform X1

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049250.1 Alternate UU_Cfam_GSD_1.0

Range

34536488..34840936 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038579701.1 → XP_038435629.1 matrix metalloproteinase-16 isoform X2

UniProtKB/TrEMBL

A0A8C0T0T4

Conserved Domains (4) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 499

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain
XM_038579700.1 → XP_038435628.1 matrix metalloproteinase-16 isoform X1

UniProtKB/TrEMBL

A0A8C0KH15, A0A8C0PE40, A0A8C0T0T4, A0A8I3S0N4

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006611.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

34056176..34360687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022412468.2 → XP_022268176.1 matrix metalloproteinase-16 isoform X2

UniProtKB/TrEMBL

A0A8C0T0T4

Conserved Domains (4) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 499

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain
XM_544165.8 → XP_544165.3 matrix metalloproteinase-16 isoform X1

UniProtKB/TrEMBL

A0A8C0KH15, A0A8C0PE40, A0A8C0T0T4, A0A8I3S0N4

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)