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PLCE1 phospholipase C epsilon 1 [ Canis lupus familiaris (dog) ]

Gene ID: 486808, updated on 5-Mar-2024

Summary

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Official Symbol
PLCE1provided by VGNC
Official Full Name
phospholipase C epsilon 1provided by VGNC
Primary source
VGNC:VGNC:44650
See related
Ensembl:ENSCAFG00845020610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 28
Exon count:
34
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (8429089..8751544)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (8387216..8659466)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (8391272..8663966)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (8190819..8462238)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (8220652..8493537)

Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member G1 Neighboring gene uncharacterized LOC111093038 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene NOC3 like DNA replication regulator Neighboring gene TBC1 domain family member 12 Neighboring gene uncharacterized LOC111093037 Neighboring gene helicase, lymphoid specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
XP_038295575.1
XP_038295576.1
XP_038295577.1
XP_038295578.1
XP_038295579.1
XP_038295580.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136565.2 → NP_001130037.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000374
    UniProtKB/TrEMBL
    A0A8C0N1R9, A0A8C0TEH2, A0A8I3P6K5
    Related
    ENSCAFP00845029066.1, ENSCAFT00845037112.1
    Conserved Domains (6) summary
    cd08596
    Location:1400 → 1842
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1327 → 1992
    PLN02952; phosphoinositide phospholipase C
    cd16203
    Location:1207 → 1387
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2143 → 2244
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:2016 → 2123
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cl02485
    Location:540 → 833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051832.1 Reference ROS_Cfam_1.0

    Range
    8429089..8751544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038439647.1 → XP_038295575.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MZT9, A0A8C0TEH2, A0A8I3PB87
    Related
    ENSCAFP00845028813.1, ENSCAFT00845036800.1
    Conserved Domains (6) summary
    cd08596
    Location:1400 → 1856
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02228
    Location:1341 → 2006
    PLN02228; Phosphoinositide phospholipase C
    cd16203
    Location:1207 → 1387
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2157 → 2258
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:2030 → 2137
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cl02485
    Location:540 → 833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_038439652.1 → XP_038295580.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0MV61, A0A8I3P734
    Conserved Domains (6) summary
    cd00275
    Location:1851 → 1963
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:1400 → 1812
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    cd16203
    Location:1207 → 1387
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2113 → 2214
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:1986 → 2093
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cl02485
    Location:540 → 833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_038439648.1 → XP_038295576.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TEH2
    Conserved Domains (6) summary
    cd08596
    Location:1400 → 1855
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02228
    Location:1341 → 2005
    PLN02228; Phosphoinositide phospholipase C
    cd16203
    Location:1207 → 1387
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2156 → 2257
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:2029 → 2136
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cl02485
    Location:540 → 833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_038439649.1 → XP_038295577.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N1R9, A0A8C0TEH2, A0A8I3P6K5
    Conserved Domains (6) summary
    cd08596
    Location:1400 → 1842
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1327 → 1992
    PLN02952; phosphoinositide phospholipase C
    cd16203
    Location:1207 → 1387
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2143 → 2244
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:2016 → 2123
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cl02485
    Location:540 → 833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. XM_038439650.1 → XP_038295578.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0QVA7
    Conserved Domains (6) summary
    cd08596
    Location:1384 → 1840
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02228
    Location:1325 → 1990
    PLN02228; Phosphoinositide phospholipase C
    cd16203
    Location:1191 → 1371
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2141 → 2242
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:2014 → 2121
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cl02485
    Location:540 → 833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. XM_038439651.1 → XP_038295579.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0TEH2
    Conserved Domains (6) summary
    cd08596
    Location:1384 → 1826
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1311 → 1976
    PLN02952; phosphoinositide phospholipase C
    cd16203
    Location:1191 → 1371
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2127 → 2228
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:2000 → 2107
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cl02485
    Location:540 → 833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049288.1 Alternate UMICH_Zoey_3.1

    Range
    8190819..8462238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

    Range
    8220652..8493537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

    Range
    8391272..8663966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    8387216..8659466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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