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FAS Fas cell surface death receptor [ Canis lupus familiaris (dog) ]

Gene ID: 486469, updated on 5-Mar-2024

Summary

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Official Symbol
FASprovided by VGNC
Official Full Name
Fas cell surface death receptorprovided by VGNC
Primary source
VGNC:VGNC:40734
See related
Ensembl:ENSCAFG00845029855
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (40322559..40347441)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (38489983..38514797)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (39027502..39052301)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (38193452..38217927)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (37756887..37781708)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene STAM binding protein like 1 Neighboring gene uncharacterized LOC111092516 Neighboring gene actin alpha 2, smooth muscle Neighboring gene uncharacterized LOC119866258 Neighboring gene uncharacterized LOC119866259 Neighboring gene proline-rich extensin-like protein EPR1 Neighboring gene uncharacterized LOC111092672

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CD95 (FAS) and CD178 (FASL) induce the apoptosis of CD4+ and CD8+ cells isolated from the peripheral blood and spleen of dogs naturally infected with Leishmania spp. Silva KL, et al. Vet Parasitol, 2013 Nov 8. PMID 23920055

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results enhance the current understanding of the immune response in dogs infected with L. chagasi, facilitating the future development of therapeutic interventions to reduce lymphocyte depletion.
    Title: CD95 (FAS) and CD178 (FASL) induce the apoptosis of CD4+ and CD8+ cells isolated from the peripheral blood and spleen of dogs naturally infected with Leishmania spp.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in necroptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 6
Names
Fas (TNF receptor superfamily, member 6)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    40322559..40347441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437712.1 → XP_038293640.1  tumor necrosis factor receptor superfamily member 6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LN93, A0A8C0SZA4, A0A8I3Q9L2, A0A8P0NHD1
    Related
    ENSCAFP00845041513.1, ENSCAFT00845052870.1
    Conserved Domains (2) summary
    cd08316
    Location:221 → 313
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:39 → 167
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

  2. XM_038437711.1 → XP_038293639.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LRD8, A0A8C0SZA4, A0A8I3QWC0, A0A8P0SJS7
    Related
    ENSCAFP00845041530.1, ENSCAFT00845052891.1
    Conserved Domains (2) summary
    cd08316
    Location:228 → 320
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:46 → 174
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    38193452..38217927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512587.1 → XP_038368515.1  tumor necrosis factor receptor superfamily member 6 isoform X2

    Conserved Domains (2) summary
    cd08316
    Location:221 → 313
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:39 → 167
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

  2. XM_038512586.1 → XP_038368514.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    Conserved Domains (2) summary
    cd08316
    Location:228 → 320
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:46 → 174
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    37756887..37781708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640291.1 → XP_038496219.1  tumor necrosis factor receptor superfamily member 6 isoform X2

    Conserved Domains (2) summary
    cd08316
    Location:221 → 313
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:39 → 167
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

  2. XM_038640290.1 → XP_038496218.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    Conserved Domains (2) summary
    cd08316
    Location:228 → 320
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:46 → 174
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    39027502..39052301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038576079.1 → XP_038432007.1  tumor necrosis factor receptor superfamily member 6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SZA4

  2. XM_038576077.1 → XP_038432005.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SZA4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38489983..38514797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005636650.3 → XP_005636707.1  tumor necrosis factor receptor superfamily member 6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LN93, A0A8C0SZA4, A0A8I3Q9L2, A0A8P0NHD1
    Conserved Domains (2) summary
    cd08316
    Location:221 → 313
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:39 → 167
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

  2. XM_022410445.2 → XP_022266153.2  tumor necrosis factor receptor superfamily member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LRD8, A0A8C0SZA4, A0A8I3QWC0, A0A8P0SJS7
    Conserved Domains (2) summary
    cd08316
    Location:228 → 320
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:46 → 174
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
Nucleotide Protein
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