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LIMK2 LIM domain kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 486363, updated on 5-Mar-2024

Summary

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Official Symbol
LIMK2provided by VGNC
Official Full Name
LIM domain kinase 2provided by VGNC
Primary source
VGNC:VGNC:52937
See related
Ensembl:ENSCAFG00845022335
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (24565985..24625824)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (24052624..24112447)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (24592678..24652526)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (24269022..24329024)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (24530984..24590898)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase J Neighboring gene phospholipase A2 group III Neighboring gene ring finger protein 185 Neighboring gene uncharacterized LOC111092639 Neighboring gene uncharacterized LOC106557828 Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene POZ/BTB and AT hook containing zinc finger 1 Neighboring gene collagen alpha-1(I) chain-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LIM domain kinase 2
XP_022266335.1
XP_038293215.1
XP_038293216.1
XP_038293217.1
XP_038368111.1
XP_038368112.1
XP_038368113.1
XP_038431612.1
XP_038431613.1
XP_038431614.1
XP_038495807.1
XP_038495808.1
XP_038495809.1
XP_543489.2
XP_852696.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    24565985..24625824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437287.1 → XP_038293215.1  LIM domain kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PL08, A0A8P0NF16
    Conserved Domains (4) summary
    cd09465
    Location:102 → 160
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:372 → 643
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:188 → 271
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 100
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_038437288.1 → XP_038293216.1  LIM domain kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JJE0, A0A8C0RN34, A0A8I3PL08, A0A8I3S5T7, A0A8P0NF16
    Related
    ENSCAFP00845031308.1, ENSCAFT00845039983.1
    Conserved Domains (4) summary
    cd09465
    Location:67 → 125
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:337 → 608
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:153 → 236
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 65
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_038437289.1 → XP_038293217.1  LIM domain kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JLG0, A0A8C0TMY9, A0A8I3PL08, A0A8P0NF16
    Related
    ENSCAFP00845031397.1, ENSCAFT00845040095.1
    Conserved Domains (4) summary
    cd09465
    Location:46 → 104
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:316 → 587
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:132 → 215
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:15 → 44
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    24269022..24329024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512183.1 → XP_038368111.1  LIM domain kinase 2 isoform X1

    Conserved Domains (4) summary
    cd09465
    Location:102 → 160
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:372 → 643
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:188 → 271
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 100
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_038512184.1 → XP_038368112.1  LIM domain kinase 2 isoform X2

    Conserved Domains (4) summary
    cd09465
    Location:67 → 125
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:337 → 608
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:153 → 236
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 65
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_038512185.1 → XP_038368113.1  LIM domain kinase 2 isoform X3

    Conserved Domains (4) summary
    cd09465
    Location:46 → 104
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:316 → 587
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:132 → 215
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:15 → 44
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    24530984..24590898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038639879.1 → XP_038495807.1  LIM domain kinase 2 isoform X1

    Conserved Domains (4) summary
    cd09465
    Location:102 → 160
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:372 → 643
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:188 → 271
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 100
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_038639880.1 → XP_038495808.1  LIM domain kinase 2 isoform X2

    Conserved Domains (4) summary
    cd09465
    Location:67 → 125
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:337 → 608
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:153 → 236
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 65
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_038639881.1 → XP_038495809.1  LIM domain kinase 2 isoform X3

    Conserved Domains (4) summary
    cd09465
    Location:46 → 104
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:316 → 587
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:132 → 215
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:15 → 44
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    24592678..24652526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038575684.1 → XP_038431612.1  LIM domain kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PL08, A0A8P0NF16
    Conserved Domains (4) summary
    cd09465
    Location:102 → 160
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:372 → 643
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:188 → 271
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 100
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_038575685.1 → XP_038431613.1  LIM domain kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JJE0, A0A8C0RN34, A0A8I3PL08, A0A8I3S5T7, A0A8P0NF16
    Conserved Domains (4) summary
    cd09465
    Location:67 → 125
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:337 → 608
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:153 → 236
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 65
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_038575686.1 → XP_038431614.1  LIM domain kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JLG0, A0A8C0TMY9, A0A8I3PL08, A0A8P0NF16
    Conserved Domains (4) summary
    cd09465
    Location:46 → 104
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:316 → 587
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:132 → 215
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:15 → 44
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24052624..24112447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022410627.2 → XP_022266335.1  LIM domain kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PL08, A0A8P0NF16
    Conserved Domains (4) summary
    cd09465
    Location:102 → 160
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:372 → 643
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:188 → 271
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 100
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_847603.5 → XP_852696.1  LIM domain kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JJE0, A0A8C0RN34, A0A8I3PL08, A0A8I3S5T7, A0A8P0NF16
    Conserved Domains (4) summary
    cd09465
    Location:67 → 125
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:337 → 608
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:153 → 236
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:12 → 65
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_543489.6 → XP_543489.2  LIM domain kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JLG0, A0A8C0TMY9, A0A8I3PL08, A0A8P0NF16
    Conserved Domains (4) summary
    cd09465
    Location:46 → 104
    LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
    cd14222
    Location:316 → 587
    STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
    pfam00595
    Location:132 → 215
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:15 → 44
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
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