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CHEK2 checkpoint kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 486338, updated on 5-Mar-2024

Summary

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Official Symbol
CHEK2provided by VGNC
Official Full Name
checkpoint kinase 2provided by VGNC
Primary source
VGNC:VGNC:39209
See related
Ensembl:ENSCAFG00845030072
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (22425372..22519047, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (21923947..22017275, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (22461722..22555609, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (22135806..22229383, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (22399429..22492792, complement)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene 40S ribosomal protein S12-like Neighboring gene 40S ribosomal protein S18-like Neighboring gene U6 spliceosomal RNA Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone Neighboring gene coiled-coil domain containing 117 Neighboring gene X-box binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation. Marfe G, et al. Res Vet Sci, 2012 Aug. PMID 21890154

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. case report, mutations and p53 mutation resulting in multiple primary neoplasms and SIRT1 down-regulation
    Title: A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase Chk2
Names
CHK2 checkpoint homolog
XP_005636449.1
XP_005636450.1
XP_005636451.1
XP_005636452.1
XP_005636453.1
XP_005636454.1
XP_013963328.1
XP_013963330.1
XP_022266203.1
XP_022266205.1
XP_038293049.1
XP_038293050.1
XP_038293051.1
XP_038293052.1
XP_038293053.1
XP_038293054.1
XP_038293055.1
XP_038293056.1
XP_038293057.1
XP_038293058.1
XP_038293059.1
XP_038293060.1
XP_038315309.1
XP_038315310.1
XP_038367954.1
XP_038367955.1
XP_038367956.1
XP_038367957.1
XP_038367958.1
XP_038367959.1
XP_038367960.1
XP_038367961.1
XP_038367963.1
XP_038367964.1
XP_038367965.1
XP_038367966.1
XP_038431453.1
XP_038431454.1
XP_038431455.1
XP_038431456.1
XP_038431457.1
XP_038431458.1
XP_038431459.1
XP_038431460.1
XP_038431461.1
XP_038431462.1
XP_038431463.1
XP_038431464.1
XP_038495645.1
XP_038495646.1
XP_038495647.1
XP_038495648.1
XP_038495649.1
XP_038495650.1
XP_038495652.1
XP_038495653.1
XP_038495654.1
XP_038495655.1
XP_038495656.1
XP_038495657.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    22425372..22519047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437127.1 → XP_038293055.1  serine/threonine-protein kinase Chk2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0R5W5
    Conserved Domains (2) summary
    cd00060
    Location:29 → 118
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:129 → 402
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. XM_038437124.1 → XP_038293052.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  3. XM_038437122.1 → XP_038293050.1  serine/threonine-protein kinase Chk2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LD25
    Conserved Domains (2) summary
    cd00060
    Location:113 → 222
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:233 → 506
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  4. XM_038437125.1 → XP_038293053.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  5. XM_038437123.1 → XP_038293051.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Related
    ENSCAFP00845041916.1, ENSCAFT00845053359.1
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  6. XM_038437131.1 → XP_038293059.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  7. XM_038437121.1 → XP_038293049.1  serine/threonine-protein kinase Chk2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0PGQ8, A0A8I3QAH4
    Related
    ENSCAFP00845041946.1, ENSCAFT00845053394.1
    Conserved Domains (2) summary
    cd00060
    Location:140 → 249
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:260 → 533
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  8. XM_038437126.1 → XP_038293054.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  9. XM_038437130.1 → XP_038293058.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  10. XM_038437132.1 → XP_038293060.1  serine/threonine-protein kinase Chk2 isoform X7

    Conserved Domains (1) summary
    cd14084
    Location:1 → 265
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  11. XM_038437129.1 → XP_038293057.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  12. XM_038437128.1 → XP_038293056.1  serine/threonine-protein kinase Chk2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0R5W5
    Conserved Domains (2) summary
    cd00060
    Location:12 → 101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:112 → 385
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    22135806..22229383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512032.1 → XP_038367960.1  serine/threonine-protein kinase Chk2 isoform X4

    Conserved Domains (2) summary
    cd00060
    Location:29 → 118
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:129 → 402
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. XM_038512029.1 → XP_038367957.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  3. XM_038512027.1 → XP_038367955.1  serine/threonine-protein kinase Chk2 isoform X2

    Conserved Domains (2) summary
    cd00060
    Location:113 → 222
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:233 → 506
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  4. XM_038512030.1 → XP_038367958.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  5. XM_038512028.1 → XP_038367956.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  6. XM_038512037.1 → XP_038367965.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  7. XM_038512026.1 → XP_038367954.1  serine/threonine-protein kinase Chk2 isoform X1

    Conserved Domains (2) summary
    cd00060
    Location:140 → 249
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:260 → 533
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  8. XM_038512031.1 → XP_038367959.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  9. XM_038512036.1 → XP_038367964.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  10. XM_038512038.1 → XP_038367966.1  serine/threonine-protein kinase Chk2 isoform X7

    Conserved Domains (1) summary
    cd14084
    Location:1 → 265
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  11. XM_038512035.1 → XP_038367963.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  12. XM_038512033.1 → XP_038367961.1  serine/threonine-protein kinase Chk2 isoform X5

    Conserved Domains (2) summary
    cd00060
    Location:12 → 101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:112 → 385
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    22399429..22492792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038639724.1 → XP_038495652.1  serine/threonine-protein kinase Chk2 isoform X4

    Conserved Domains (2) summary
    cd00060
    Location:29 → 118
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:129 → 402
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. XM_038639720.1 → XP_038495648.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  3. XM_038639718.1 → XP_038495646.1  serine/threonine-protein kinase Chk2 isoform X2

    Conserved Domains (2) summary
    cd00060
    Location:113 → 222
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:233 → 506
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  4. XM_038639721.1 → XP_038495649.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  5. XM_038639719.1 → XP_038495647.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  6. XM_038639728.1 → XP_038495656.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  7. XM_038639717.1 → XP_038495645.1  serine/threonine-protein kinase Chk2 isoform X1

    Conserved Domains (2) summary
    cd00060
    Location:140 → 249
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:260 → 533
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  8. XM_038639722.1 → XP_038495650.1  serine/threonine-protein kinase Chk2 isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  9. XM_038639727.1 → XP_038495655.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  10. XM_038639729.1 → XP_038495657.1  serine/threonine-protein kinase Chk2 isoform X7

    Conserved Domains (1) summary
    cd14084
    Location:1 → 265
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  11. XM_038639726.1 → XP_038495654.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  12. XM_038639725.1 → XP_038495653.1  serine/threonine-protein kinase Chk2 isoform X5

    Conserved Domains (2) summary
    cd00060
    Location:12 → 101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:112 → 385
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    22461722..22555609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038575531.1 → XP_038431459.1  serine/threonine-protein kinase Chk2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0R5W5
    Conserved Domains (2) summary
    cd00060
    Location:29 → 118
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:129 → 402
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. XM_038575528.1 → XP_038431456.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  3. XM_038575526.1 → XP_038431454.1  serine/threonine-protein kinase Chk2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LD25
    Conserved Domains (2) summary
    cd00060
    Location:113 → 222
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:233 → 506
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  4. XM_038575529.1 → XP_038431457.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  5. XM_038575527.1 → XP_038431455.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  6. XM_038575535.1 → XP_038431463.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  7. XM_038575525.1 → XP_038431453.1  serine/threonine-protein kinase Chk2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0PGQ8, A0A8I3QAH4
    Conserved Domains (2) summary
    cd00060
    Location:140 → 249
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:260 → 533
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  8. XM_038575530.1 → XP_038431458.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  9. XM_038575534.1 → XP_038431462.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  10. XM_038575536.1 → XP_038431464.1  serine/threonine-protein kinase Chk2 isoform X7

    Conserved Domains (1) summary
    cd14084
    Location:1 → 265
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  11. XM_038575533.1 → XP_038431461.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  12. XM_038575532.1 → XP_038431460.1  serine/threonine-protein kinase Chk2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0R5W5
    Conserved Domains (2) summary
    cd00060
    Location:12 → 101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:112 → 385
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21923947..22017275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005636395.4 → XP_005636452.1  serine/threonine-protein kinase Chk2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0R5W5
    Conserved Domains (2) summary
    cd00060
    Location:29 → 118
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:129 → 402
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. XM_005636393.4 → XP_005636450.1  serine/threonine-protein kinase Chk2 isoform X3

    See identical proteins and their annotated locations for XP_005636450.1

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  3. XM_038459382.1 → XP_038315310.1  serine/threonine-protein kinase Chk2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LD25
    Conserved Domains (2) summary
    cd00060
    Location:113 → 222
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:233 → 506
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  4. XM_005636394.4 → XP_005636451.1  serine/threonine-protein kinase Chk2 isoform X3

    See identical proteins and their annotated locations for XP_005636451.1

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  5. XM_005636392.4 → XP_005636449.1  serine/threonine-protein kinase Chk2 isoform X3

    See identical proteins and their annotated locations for XP_005636449.1

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  6. XM_005636396.4 → XP_005636453.1  serine/threonine-protein kinase Chk2 isoform X6

    See identical proteins and their annotated locations for XP_005636453.1

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  7. XM_038459381.1 → XP_038315309.1  serine/threonine-protein kinase Chk2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0PGQ8, A0A8I3QAH4
    Conserved Domains (2) summary
    cd00060
    Location:140 → 249
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:260 → 533
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  8. XM_022410495.2 → XP_022266203.1  serine/threonine-protein kinase Chk2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LD25, A0A8C0Z778
    Conserved Domains (2) summary
    cd00060
    Location:94 → 203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:214 → 487
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  9. XM_022410497.2 → XP_022266205.1  serine/threonine-protein kinase Chk2 isoform X6

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  10. XM_014107855.3 → XP_013963330.1  serine/threonine-protein kinase Chk2 isoform X7

    Conserved Domains (1) summary
    cd14084
    Location:1 → 265
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  11. XM_005636397.4 → XP_005636454.1  serine/threonine-protein kinase Chk2 isoform X6

    See identical proteins and their annotated locations for XP_005636454.1

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  12. XM_014107853.3 → XP_013963328.1  serine/threonine-protein kinase Chk2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0R5W5
    Conserved Domains (2) summary
    cd00060
    Location:12 → 101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:112 → 385
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
Nucleotide Protein
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