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PXN paxillin [ Canis lupus familiaris (dog) ]

Gene ID: 486299, updated on 5-Mar-2024

Summary

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Official Symbol
PXNprovided by VGNC
Official Full Name
paxillinprovided by VGNC
Primary source
VGNC:VGNC:52959
See related
Ensembl:ENSCAFG00845029597
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PXN in Genome Data Viewer
Location:
chromosome: 26
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (16424969..16473447, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (16161797..16210046, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (16504096..16552543, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (16385989..16434224, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (16463118..16511352, complement)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC119866174 Neighboring gene U4 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene sirtuin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt. Huang Y, et al. Am J Physiol Lung Cell Mol Physiol, 2020 May 1. PMID 32130030, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt.
    Title: Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
paxillin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    16424969..16473447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038436906.1 → XP_038292834.1  paxillin isoform X1

    UniProtKB/TrEMBL
    A0A8C0T9Y7, A0A8I3Q0P3
    Related
    ENSCAFP00845041134.1, ENSCAFT00845052430.1
    Conserved Domains (5) summary
    cd09338
    Location:964 → 1016
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:905 → 956
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1023 → 1074
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:846 → 898
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  2. XM_038436908.1 → XP_038292836.1  paxillin isoform X3

    UniProtKB/TrEMBL
    A0A8C0PD14
    Conserved Domains (5) summary
    cd09338
    Location:481 → 533
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:422 → 473
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:540 → 591
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:363 → 415
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:93 → 292
    Paxillin; Paxillin family

  3. XM_038436907.1 → XP_038292835.1  paxillin isoform X2

    UniProtKB/TrEMBL
    A0A8C0RS89
    Related
    ENSCAFP00845041147.1, ENSCAFT00845052446.1
    Conserved Domains (5) summary
    cd09338
    Location:514 → 566
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:455 → 506
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:573 → 624
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:396 → 448
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:93 → 292
    Paxillin; Paxillin family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    16385989..16434224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038511800.1 → XP_038367728.1  paxillin isoform X5

    Conserved Domains (5) summary
    cd09338
    Location:442 → 494
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:383 → 434
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:501 → 552
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:324 → 376
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  2. XM_038511799.1 → XP_038367727.1  paxillin isoform X4

    Conserved Domains (5) summary
    cd09338
    Location:475 → 527
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:416 → 467
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:534 → 585
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:357 → 409
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  3. XM_038511797.1 → XP_038367725.1  paxillin isoform X1

    Conserved Domains (5) summary
    cd09338
    Location:964 → 1016
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:905 → 956
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1023 → 1074
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:846 → 898
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    16463118..16511352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038639484.1 → XP_038495412.1  paxillin isoform X1

  2. XM_038639486.1 → XP_038495414.1  paxillin isoform X3

  3. XM_038639485.1 → XP_038495413.1  paxillin isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    16504096..16552543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038575296.1 → XP_038431224.1  paxillin isoform X1

    UniProtKB/TrEMBL
    A0A8C0T9Y7, A0A8I3Q0P3
    Conserved Domains (5) summary
    cd09338
    Location:964 → 1016
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:905 → 956
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1023 → 1074
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:846 → 898
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  2. XM_038575298.1 → XP_038431226.1  paxillin isoform X3

    UniProtKB/TrEMBL
    A0A8C0PD14
    Conserved Domains (5) summary
    cd09338
    Location:481 → 533
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:422 → 473
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:540 → 591
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:363 → 415
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:93 → 292
    Paxillin; Paxillin family

  3. XM_038575297.1 → XP_038431225.1  paxillin isoform X2

    UniProtKB/TrEMBL
    A0A8C0RS89
    Conserved Domains (5) summary
    cd09338
    Location:514 → 566
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:455 → 506
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:573 → 624
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:396 → 448
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:93 → 292
    Paxillin; Paxillin family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    16161797..16210046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038459459.1 → XP_038315387.1  paxillin isoform X1

    UniProtKB/TrEMBL
    A0A8C0T9Y7, A0A8I3Q0P3
    Conserved Domains (5) summary
    cd09338
    Location:964 → 1016
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:905 → 956
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1023 → 1074
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:846 → 898
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:54 → 253
    Paxillin; Paxillin family

  2. XM_022410171.1 → XP_022265879.1  paxillin isoform X3

    UniProtKB/TrEMBL
    A0A8C0PD14
    Conserved Domains (5) summary
    cd09338
    Location:481 → 533
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:422 → 473
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:540 → 591
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:363 → 415
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:93 → 292
    Paxillin; Paxillin family

  3. XM_022410169.1 → XP_022265877.1  paxillin isoform X2

    UniProtKB/TrEMBL
    A0A8C0RS89
    Conserved Domains (5) summary
    cd09338
    Location:514 → 566
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:455 → 506
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:573 → 624
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:396 → 448
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:93 → 292
    Paxillin; Paxillin family
Nucleotide Protein
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