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IRS1 insulin receptor substrate 1 [ Canis lupus familiaris (dog) ]

Gene ID: 486148, updated on 5-Mar-2024

Summary

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Official Symbol
IRS1provided by VGNC
Official Full Name
insulin receptor substrate 1provided by VGNC
Primary source
VGNC:VGNC:54317
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
2
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (39876307..39936286, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (40246368..40306296, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (39826700..39886691, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (39811057..39873068, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (39647771..39707665, complement)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102157117 Neighboring gene uncharacterized LOC119865854 Neighboring gene uncharacterized LOC119865953 Neighboring gene rhomboid domain containing 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC102157244

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    39876307..39936286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435585.1 → XP_038291513.1  insulin receptor substrate 1

    UniProtKB/TrEMBL
    A0A8C0L2U0, A0A8C0PJD0, A0A8C0T9P1
    Conserved Domains (2) summary
    cd01204
    Location:160 → 263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11 → 118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    39811057..39873068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510517.1 → XP_038366445.1  insulin receptor substrate 1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    39647771..39707665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638294.1 → XP_038494222.1  insulin receptor substrate 1

    Conserved Domains (2) summary
    cd01204
    Location:160 → 263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11 → 118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    39826700..39886691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038573977.1 → XP_038429905.1  insulin receptor substrate 1

    UniProtKB/TrEMBL
    A0A8C0T9P1
    Conserved Domains (2) summary
    cd01204
    Location:160 → 263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11 → 118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    40246368..40306296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_543274.7 → XP_543274.4  insulin receptor substrate 1

    UniProtKB/TrEMBL
    A0A8C0T9P1
    Conserved Domains (2) summary
    cd01204
    Location:160 → 263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11 → 118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
Nucleotide Protein
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