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DOK2 docking protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 486133, updated on 11-Apr-2024

Summary

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Official Symbol
DOK2provided by VGNC
Official Full Name
docking protein 2provided by VGNC
Primary source
VGNC:VGNC:40056
See related
Ensembl:ENSCAFG00845028659
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (35538727..35549625)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (35916511..35927422)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (35493865..35504771)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (35483726..35494648)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (35338286..35349197)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092483 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene exportin 7 Neighboring gene uncharacterized LOC119865951 Neighboring gene GDNF family receptor alpha 2 Neighboring gene putative elongation factor 1-alpha-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
docking protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    35538727..35549625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435518.1 → XP_038291446.1  docking protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q1A9
    Related
    ENSCAFP00845039691.1, ENSCAFT00845050631.1
    Conserved Domains (3) summary
    PHA03247
    Location:228 → 386
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:136 → 233
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:3 → 101
    PH-like; Pleckstrin homology-like domain

  2. XM_038435513.1 → XP_038291441.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  3. XM_038435517.1 → XP_038291445.1  docking protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3Z8
    Conserved Domains (3) summary
    PHA03247
    Location:240 → 398
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:148 → 245
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  4. XM_038435516.1 → XP_038291444.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  5. XM_038435515.1 → XP_038291443.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  6. XM_038435514.1 → XP_038291442.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    35483726..35494648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510459.1 → XP_038366387.1  docking protein 2 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:228 → 386
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:136 → 233
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:3 → 101
    PH-like; Pleckstrin homology-like domain

  2. XM_038510455.1 → XP_038366383.1  docking protein 2 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  3. XM_038510458.1 → XP_038366386.1  docking protein 2 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:240 → 398
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:148 → 245
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  4. XM_038510457.1 → XP_038366385.1  docking protein 2 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  5. XM_038510456.1 → XP_038366384.1  docking protein 2 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    35338286..35349197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638226.1 → XP_038494154.1  docking protein 2 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:228 → 386
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:136 → 233
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:3 → 101
    PH-like; Pleckstrin homology-like domain

  2. XM_038638225.1 → XP_038494153.1  docking protein 2 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:240 → 398
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:148 → 245
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  3. XM_038638224.1 → XP_038494152.1  docking protein 2 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  4. XM_038638222.1 → XP_038494150.1  docking protein 2 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    35493865..35504771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038573908.1 → XP_038429836.1  docking protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q1A9
    Conserved Domains (3) summary
    PHA03247
    Location:228 → 386
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:136 → 233
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:3 → 101
    PH-like; Pleckstrin homology-like domain

  2. XM_038573907.1 → XP_038429835.1  docking protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3Z8
    Conserved Domains (3) summary
    PHA03247
    Location:240 → 398
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:148 → 245
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  3. XM_038573906.1 → XP_038429834.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  4. XM_038573905.1 → XP_038429833.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  5. XM_038573904.1 → XP_038429832.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35916511..35927422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038458181.1 → XP_038314109.1  docking protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q1A9
    Conserved Domains (3) summary
    PHA03247
    Location:228 → 386
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:136 → 233
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:3 → 101
    PH-like; Pleckstrin homology-like domain

  2. XM_038458177.1 → XP_038314105.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  3. XM_038458180.1 → XP_038314108.1  docking protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L3Z8
    Conserved Domains (3) summary
    PHA03247
    Location:240 → 398
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:148 → 245
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  4. XM_038458179.1 → XP_038314107.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  5. XM_543259.7 → XP_543259.4  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

  6. XM_038458178.1 → XP_038314106.1  docking protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PI29, A0A8P0NC66
    Conserved Domains (3) summary
    PHA03247
    Location:241 → 399
    PHA03247; large tegument protein UL36; Provisional
    cd01203
    Location:149 → 246
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:7 → 114
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
Nucleotide Protein
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