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GATA4 GATA binding protein 4 [ Canis lupus familiaris (dog) ]

Gene ID: 486079, updated on 5-Mar-2024

Summary

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Official Symbol
GATA4provided by VGNC
Official Full Name
GATA binding protein 4provided by VGNC
Primary source
VGNC:VGNC:54949
See related
Ensembl:ENSCAFG00845019258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (26280507..26366154, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (26784428..26835191, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (26283313..26334650, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (26235249..26286037, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (26131847..26182607, complement)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene farnesyl-diphosphate farnesyltransferase 1 Neighboring gene nei like DNA glycosylase 2 Neighboring gene uncharacterized LOC100685020 Neighboring gene BLK proto-oncogene, Src family tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation, characterization and genetic analysis of canine GATA4 gene in a family of Doberman Pinschers with an atrial septal defect. Lee SA, et al. J Genet, 2007 Dec. PMID 18305343

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GATA4 may not be responsible for the atrial septal defect in the dogs used in this study
    Title: Isolation, characterization and genetic analysis of canine GATA4 gene in a family of Doberman Pinschers with an atrial septal defect.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcription factor GATA-4
Names
GATA-binding factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048112.1 → NP_001041577.1  transcription factor GATA-4

    See identical proteins and their annotated locations for NP_001041577.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ666280
    UniProtKB/Swiss-Prot
    Q0Q0E4
    UniProtKB/TrEMBL
    A0A8C0TK74
    Conserved Domains (2) summary
    cd00202
    Location:270 → 321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1 → 205
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    26280507..26366154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038434567.1 → XP_038290495.1  transcription factor GATA-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KFU3, A0A8C0TK74
    Conserved Domains (2) summary
    cd00202
    Location:271 → 322
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1 → 205
    GATA-N; GATA-type transcription activator, N-terminal

  2. XM_038434566.1 → XP_038290494.1  transcription factor GATA-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KFU3, A0A8C0TK74
    Conserved Domains (2) summary
    cd00202
    Location:271 → 322
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1 → 205
    GATA-N; GATA-type transcription activator, N-terminal

  3. XM_038434568.1 → XP_038290496.1  transcription factor GATA-4 isoform X2

    UniProtKB/Swiss-Prot
    Q0Q0E4
    UniProtKB/TrEMBL
    A0A8C0TK74
    Related
    ENSCAFP00845026636.1, ENSCAFT00845034032.1
    Conserved Domains (2) summary
    cd00202
    Location:270 → 321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1 → 205
    GATA-N; GATA-type transcription activator, N-terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    26235249..26286037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    26131847..26182607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    26283313..26334650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26784428..26835191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0Q0E4.1 GenPept UniProtKB/Swiss-Prot:Q0Q0E4

Gene LinkOut

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