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PLCG1 phospholipase C gamma 1 [ Canis lupus familiaris (dog) ]

Gene ID: 485874, updated on 5-Mar-2024

Summary

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Official Symbol
PLCG1provided by VGNC
Official Full Name
phospholipase C gamma 1provided by VGNC
Primary source
VGNC:VGNC:44651
See related
Ensembl:ENSCAFG00845030031
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
32
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (29883241..29919530)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (28823106..28859401)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (29752157..29788483)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (29152120..29188420)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (29256001..29292271)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152405 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like Neighboring gene DNA topoisomerase I Neighboring gene uncharacterized LOC102152517 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene uncharacterized LOC111092095 Neighboring gene lipin 3 Neighboring gene elastin microfibril interfacer 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
XP_038289761.1
XP_038289762.1
XP_038313582.1
XP_038313583.1
XP_038364907.1
XP_038364908.1
XP_038428245.1
XP_038428246.1
XP_038492498.1
XP_038492499.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    29883241..29919530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038433833.1 → XP_038289761.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KG77, A0A8C0MEC3, A0A8C0Z363, A0A8I3SCI7
    Related
    ENSCAFP00845041776.1, ENSCAFT00845053205.1
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  2. XM_038433834.1 → XP_038289762.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MEC3
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    29152120..29188420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508979.1 → XP_038364907.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  2. XM_038508980.1 → XP_038364908.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    29256001..29292271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038636570.1 → XP_038492498.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  2. XM_038636571.1 → XP_038492499.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    29752157..29788483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038572317.1 → XP_038428245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KG77, A0A8C0MEC3, A0A8C0Z363, A0A8I3SCI7
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  2. XM_038572318.1 → XP_038428246.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MEC3
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    28823106..28859401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038457654.1 → XP_038313582.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KG77, A0A8C0MEC3, A0A8C0Z363, A0A8I3SCI7
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  2. XM_038457655.1 → XP_038313583.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MEC3
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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