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HCK HCK proto-oncogene, Src family tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 485828, updated on 11-Apr-2024

Summary

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Official Symbol
HCKprovided by VGNC
Official Full Name
HCK proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:41618
See related
Ensembl:ENSCAFG00845020471
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (22159696..22200184)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (21120196..21159815)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (21974379..22014637)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (21438409..21478679)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (21543401..21583860)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene XK related 7 Neighboring gene CCM2 like scaffold protein Neighboring gene transmembrane 9 superfamily member 4 Neighboring gene uncharacterized LOC111092032 Neighboring gene PLAG1 like zinc finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase HCK
Names
hemopoietic cell kinase
XP_022264841.2
XP_038289379.1
XP_038289380.1
XP_038289381.1
XP_038313796.1
XP_038364583.1
XP_038364585.1
XP_038364586.1
XP_038427873.1
XP_038427874.1
XP_038427875.1
XP_038492129.1
XP_038492130.1
XP_038492131.1
XP_542952.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    22159696..22200184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038433453.1 → XP_038289381.1  tyrosine-protein kinase HCK isoform X3

    UniProtKB/TrEMBL
    A0A8C0JTX5, A0A8C0MWN3, A0A8I3S4F9
    Related
    ENSCAFP00845028254.1, ENSCAFT00845036104.1
    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:231 → 501
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038433452.1 → XP_038289380.1  tyrosine-protein kinase HCK isoform X2

    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 343
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038433451.1 → XP_038289379.1  tyrosine-protein kinase HCK isoform X1

    Conserved Domains (3) summary
    cl15255
    Location:117 → 204
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:207 → 450
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    21438409..21478679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508658.1 → XP_038364586.1  tyrosine-protein kinase HCK isoform X3

    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:231 → 501
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038508657.1 → XP_038364585.1  tyrosine-protein kinase HCK isoform X2

    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 343
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038508655.1 → XP_038364583.1  tyrosine-protein kinase HCK isoform X1

    Conserved Domains (3) summary
    cl15255
    Location:117 → 204
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:207 → 450
    PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    21543401..21583860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038636203.1 → XP_038492131.1  tyrosine-protein kinase HCK isoform X3

    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:231 → 501
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038636202.1 → XP_038492130.1  tyrosine-protein kinase HCK isoform X2

    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 343
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038636201.1 → XP_038492129.1  tyrosine-protein kinase HCK isoform X1

    Conserved Domains (3) summary
    cl15255
    Location:117 → 204
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:207 → 450
    PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    21974379..22014637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038571947.1 → XP_038427875.1  tyrosine-protein kinase HCK isoform X3

    UniProtKB/TrEMBL
    A0A8C0JTX5, A0A8C0MWN3, A0A8I3S4F9
    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:231 → 501
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038571946.1 → XP_038427874.1  tyrosine-protein kinase HCK isoform X2

    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 343
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038571945.1 → XP_038427873.1  tyrosine-protein kinase HCK isoform X1

    Conserved Domains (3) summary
    cl15255
    Location:117 → 204
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:207 → 450
    PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21120196..21159815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_542952.7 → XP_542952.4  tyrosine-protein kinase HCK isoform X3

    UniProtKB/TrEMBL
    A0A8C0JTX5, A0A8C0MWN3, A0A8I3S4F9
    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:231 → 501
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038457868.1 → XP_038313796.1  tyrosine-protein kinase HCK isoform X2

    Conserved Domains (3) summary
    cd10363
    Location:117 → 220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 343
    PKc_like; Protein Kinases, catalytic domain

  3. XM_022409133.2 → XP_022264841.2  tyrosine-protein kinase HCK isoform X1

    Conserved Domains (3) summary
    cl15255
    Location:117 → 204
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:59 → 114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:207 → 450
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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