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heph hephaestus [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48571, updated on 10-May-2024

Summary

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Official Symbol
hephprovided by FlyBase
Official Full Name
hephaestusprovided by FlyBase
Primary source
FLYBASE:FBgn0011224
Locus tag
Dmel_CG31000
See related
AllianceGenome:FB:FBgn0011224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2094; CG2290; CG31000; Dmel\CG31000; dmPTB; DmPTB; dPTB; ema; Heph; HEPH; Hephaestus; hnRNP I; l(3)03429; l(3)j11B9; ptb; Ptb; PTB
Summary
Enables mRNA 3'-UTR binding activity and translation repressor activity, mRNA regulatory element binding. Involved in germ cell development; imaginal disc-derived wing morphogenesis; and negative regulation of oskar mRNA translation. Located in cytoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including foregut primordium; gonad; hindgut proper primordium; larval ventral nerve cord; and presumptive embryonic/larval system. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1); PTBP2 (polypyrimidine tract binding protein 2); and PTBP3 (polypyrimidine tract binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
100D3-100E2; 3-103 cM
Exon count:
31
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31846987..32015520, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27672709..27841242, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 100F Neighboring gene Ferrochelatase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45556 Neighboring gene pseudo Neighboring gene Poseidon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila polypyrimidine tract-binding protein is necessary for spermatid individualization. Robida M, et al. Proc Natl Acad Sci U S A, 2010 Jul 13. PMID 20616016, Free PMC Article
  2. Lineage-specific expression of polypyrimidine tract binding protein (PTB) in Drosophila embryos. Davis MB, et al. Mech Dev, 2002 Feb. PMID 11804786
  3. Single-molecule imaging of transcriptionally coupled and uncoupled splicing. Vargas DY, et al. Cell, 2011 Nov 23. PMID 22118462, Free PMC Article
  4. Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo. Wesley CS, et al. PLoS One, 2011. PMID 21750738, Free PMC Article
  5. Community effects in regulation of translation. Macdonald PM, et al. Elife, 2016 Apr 22. PMID 27104756, Free PMC Article

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
    Title: Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
  2. Results identified Heph as an RNA-binding protein that specifically binds to the polo upstream sequence element RNA and demonstrate that Heph has a function in polo mRNA 3'-end formation and expression, which are impaired in heph mutants.
    Title: Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster.
  3. This study provides the first comprehensive list of genes misregulated in vivo in the heph2 mutant in Drosophila.
    Title: High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis.
  4. Drosophila PTB regulates dorso-ventral patterning genes in embryos.
    Title: Drosophila polypyrimidine tract-binding protein (DmPTB) regulates dorso-ventral patterning genes in embryos.
  5. Heph is required in the germline for efficient Grk signalling to the somatic follicle cells during dorso-ventral patterning.
    Title: Drosophila Hephaestus/polypyrimidine tract binding protein is required for dorso-ventral patterning and regulation of signalling between the germline and soma.
  6. Data raise the possibility that the Drosophila embryo is divided into zones of different PTB and Notch activities based on whether or not they are linked to actin regulation.
    Title: Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo.
  7. a cytoplasmic form of PTB can associate with oskar mRNA and repress its translation, suggesting that nuclear recruitment of PTB to oskar complexes is not required for its regulatory function
    Title: Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.
  8. genetic analysis of polypyrimidine tract binding protein function in any organism and evidence that such proteins may be involved in the Notch signalling pathway
    Title: Hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster.
  9. Data show that polypyrimidine-tract binding protein appears to be a particularly potent downstream target of the sex-determination pathway in the male germline, since it can regulate multiple mRNAs.
    Title: Drosophila polypyrimidine-tract binding protein (PTB) functions specifically in the male germline.
  10. expression is patterned in the early embryo and occurs in specific mesodermal and neuronal lineages as well as in the imaginal discs and adult germline
    Title: Lineage-specific expression of polypyrimidine tract binding protein (PTB) in Drosophila embryos.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: c31897206-31887801 mobile_element_type = transposon:HB{}1605
  • Loc: c31968982-31968714 mobile_element_type = transposon:INE-1{}5306
  • Loc: c31972305-31971913 mobile_element_type = transposon:INE-1{}5305
  • Loc: c31996294-31996236 mobile_element_type = transposon:INE-1{}3999
  • Loc: c32006274-32005992 mobile_element_type = transposon:INE-1{}4005
  • Loc: c32008160-32008101 mobile_element_type = transposon:INE-1{}4009
  • Loc: c32009317-32009239 mobile_element_type = transposon:INE-1{}4013

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived wing margin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of oskar mRNA translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton polarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hephaestus
Names
CG31000-PA
CG31000-PB
CG31000-PC
CG31000-PD
CG31000-PE
CG31000-PF
CG31000-PG
CG31000-PH
CG31000-PI
CG31000-PJ
CG31000-PK
CG31000-PL
CG31000-PM
CG31000-PN
CG31000-PO
CG31000-PP
CG31000-PQ
CG31000-PR
CG31000-PS
CG31000-PT
CG31000-PU
CG31000-PV
CG31000-PW
CG31000-PY
CG31000-PZ
ectopic margin
heph-PA
heph-PB
heph-PC
heph-PD
heph-PE
heph-PF
heph-PG
heph-PH
heph-PI
heph-PJ
heph-PK
heph-PL
heph-PM
heph-PN
heph-PO
heph-PP
heph-PQ
heph-PR
heph-PS
heph-PT
heph-PU
heph-PV
heph-PW
heph-PY
heph-PZ
heterogeneous nuclear RibonucleoProtein I
polypyrimidine tract binding protein
polypyrimidine tract-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31846987..32015520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104524.3 → NP_001097994.1  hephaestus, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097994.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  2. NM_001170322.2 → NP_001163793.1  hephaestus, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF8, Q8T0H5
    Conserved Domains (5) summary
    cd12423
    Location:388 → 461
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:505 → 580
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:47 → 127
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:195 → 290
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:45 → 581
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  3. NM_001104522.3 → NP_001097992.1  hephaestus, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097992.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRI1, Q8T0H5
    Conserved Domains (5) summary
    cd12423
    Location:429 → 502
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:546 → 621
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:88 → 168
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:236 → 331
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:86 → 622
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  4. NM_176603.3 → NP_788780.1  hephaestus, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UI6
    Related
    FBpp0085240
    Conserved Domains (5) summary
    cd12423
    Location:596 → 669
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:713 → 788
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:255 → 335
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:403 → 498
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:253 → 789
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  5. NM_001170316.2 → NP_001163787.1  hephaestus, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UI6
    Conserved Domains (5) summary
    cd12423
    Location:596 → 669
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:713 → 788
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:255 → 335
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:403 → 498
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:253 → 789
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  6. NM_176602.3 → NP_788779.1  hephaestus, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788779.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085245
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  7. NM_176596.3 → NP_788773.1  hephaestus, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788773.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085241
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  8. NM_176601.3 → NP_788778.1  hephaestus, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085244
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  9. NM_176600.3 → NP_788777.1  hephaestus, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788777.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085243
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  10. NM_001260469.2 → NP_001247398.1  hephaestus, isoform W [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6P4
    Conserved Domains (5) summary
    cd12423
    Location:606 → 679
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:723 → 798
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:269 → 349
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:417 → 512
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:267 → 799
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  11. NM_170582.4 → NP_733461.2  hephaestus, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733461.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085238
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  12. NM_176597.3 → NP_788774.1  hephaestus, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085242
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  13. NM_176599.2 → NP_788776.2  hephaestus, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788776.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KRS7, Q8T0H5
    Related
    FBpp0085246
    Conserved Domains (5) summary
    cd12423
    Location:422 → 495
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:539 → 614
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:81 → 161
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:229 → 324
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:79 → 615
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  14. NM_001170319.1 → NP_001163790.1  hephaestus, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UI6
    Conserved Domains (5) summary
    cd12423
    Location:596 → 669
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:713 → 788
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:255 → 335
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:403 → 498
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:253 → 789
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  15. NM_001260470.1 → NP_001247399.1  hephaestus, isoform Y [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6W9
    Conserved Domains (5) summary
    cd12423
    Location:705 → 778
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:822 → 897
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:368 → 448
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:516 → 611
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:366 → 898
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  16. NM_176598.2 → NP_788775.1  hephaestus, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788775.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085247
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  17. NM_001170321.2 → NP_001163792.1  hephaestus, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF8, Q8T0H5
    Conserved Domains (5) summary
    cd12423
    Location:388 → 461
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:505 → 580
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:47 → 127
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:195 → 290
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:45 → 581
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  18. NM_001170320.2 → NP_001163791.1  hephaestus, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163791.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF8, Q8T0H5
    Conserved Domains (5) summary
    cd12423
    Location:388 → 461
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:505 → 580
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:47 → 127
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:195 → 290
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:45 → 581
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  19. NM_079964.3 → NP_524703.1  hephaestus, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524703.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF8, Q8T0H5
    Related
    FBpp0085239
    Conserved Domains (5) summary
    cd12423
    Location:388 → 461
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:505 → 580
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:47 → 127
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:195 → 290
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:45 → 581
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  20. NM_001300701.1 → NP_001287630.1  hephaestus, isoform Z [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287630.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHY1, Q8T0H5
    Conserved Domains (5) summary
    cd12423
    Location:411 → 484
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:528 → 603
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 604
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  21. NM_170581.2 → NP_733460.1  hephaestus, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733460.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Related
    FBpp0085237
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  22. NM_001170317.2 → NP_001163788.1  hephaestus, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  23. NM_001170323.2 → NP_001163794.1  hephaestus, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMF7, Q8T0H5, Q8WR53
    Conserved Domains (5) summary
    cd12423
    Location:415 → 488
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:532 → 607
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:74 → 154
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:222 → 317
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:72 → 608
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  24. NM_001104523.3 → NP_001097993.1  hephaestus, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097993.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3T7F7, Q7KES3
    Conserved Domains (5) summary
    cd12423
    Location:375 → 448
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:492 → 567
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12688
    Location:34 → 114
    RRM1_PTBP1_like; RNA recognition motif 1 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:182 → 277
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:32 → 568
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  25. NM_001170318.2 → NP_001163789.1  hephaestus, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163789.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ45, Q3T7F7
    Conserved Domains (5) summary
    cd12423
    Location:300 → 373
    RRM3_PTBP1_like; RNA recognition motif 3 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12425
    Location:417 → 492
    RRM4_PTBP1_like; RNA recognition motif 4 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    cd12693
    Location:107 → 202
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:1 → 493
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:1 → 39
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6P4 A0A0B4K6P4
A0A0B4K6W9 A0A0B4K6W9
A0A0B4LHY1 A0A0B4LHY1
A8JRI1 A8JRI1
E1JJ45 E1JJ45
Q3T7F7 Q3T7F7
Q7KES3 Q7KES3
Q7KRS7 Q7KRS7
Q8IMF8 Q8IMF8
Q8MT11 Q8MT11
Q8T0H5 Q8T0H5
Q8WR53 Q8WR53
Q95UI6 Q95UI6

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