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NCK1 NCK adaptor protein 1 [ Canis lupus familiaris (dog) ]

Gene ID: 485677, updated on 5-Mar-2024

Summary

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Official Symbol
NCK1provided by VGNC
Official Full Name
NCK adaptor protein 1provided by VGNC
Primary source
VGNC:VGNC:52892
See related
Ensembl:ENSCAFG00845022785
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (33827357..33903748)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (33281832..33358413)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (33819866..33896593)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (33509571..33586142)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (33575236..33651579)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene STAG1 cohesin complex component Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC100686256 Neighboring gene solute carrier family 35 member G2 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene uncharacterized LOC119865398 Neighboring gene ubiquitin-conjugating enzyme E2N pseudogene Neighboring gene interleukin 20 receptor subunit beta Neighboring gene E3 ubiquitin ligase TRAF3IP2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic protein NCK1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    33827357..33903748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432427.1 → XP_038288355.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Related
    ENSCAFP00845031501.1, ENSCAFT00845040217.1
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  2. XM_038432428.1 → XP_038288356.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  3. XM_038432430.1 → XP_038288358.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  4. XM_038432429.1 → XP_038288357.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  5. XM_038432431.1 → XP_038288359.1  cytoplasmic protein NCK1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K417, A0A8C0RI67, A0A8I3PLC1
    Related
    ENSCAFP00845031541.1, ENSCAFT00845040263.1
    Conserved Domains (3) summary
    cd10408
    Location:216 → 312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:44 → 98
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129 → 185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    33509571..33586142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038507728.1 → XP_038363656.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  2. XM_038507729.1 → XP_038363657.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  3. XM_038507730.1 → XP_038363658.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  4. XM_038507731.1 → XP_038363659.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  5. XM_038507732.1 → XP_038363660.1  cytoplasmic protein NCK1 isoform X2

    Conserved Domains (3) summary
    cd10408
    Location:216 → 312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:44 → 98
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129 → 185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    33575236..33651579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635162.1 → XP_038491090.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  2. XM_038635163.1 → XP_038491091.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  3. XM_038635165.1 → XP_038491093.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  4. XM_038635164.1 → XP_038491092.1  cytoplasmic protein NCK1 isoform X1

    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  5. XM_038635166.1 → XP_038491094.1  cytoplasmic protein NCK1 isoform X2

    Conserved Domains (3) summary
    cd10408
    Location:216 → 312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:44 → 98
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129 → 185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    33819866..33896593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038570970.1 → XP_038426898.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  2. XM_038570971.1 → XP_038426899.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  3. XM_038570972.1 → XP_038426900.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  4. XM_038570973.1 → XP_038426901.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  5. XM_038570974.1 → XP_038426902.1  cytoplasmic protein NCK1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K417, A0A8C0RI67, A0A8I3PLC1
    Conserved Domains (3) summary
    cd10408
    Location:216 → 312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:44 → 98
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129 → 185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    33281832..33358413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_846945.6 → XP_852038.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_852038.1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  2. XM_005634467.4 → XP_005634524.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005634524.1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  3. XM_005634470.4 → XP_005634527.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005634527.1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  4. XM_005634468.3 → XP_005634525.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005634525.1

    UniProtKB/TrEMBL
    A0A8C0K4L7, A0A8C0TTD9, A0A8I3S602
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  5. XM_005634471.3 → XP_005634528.1  cytoplasmic protein NCK1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0K417, A0A8C0RI67, A0A8I3PLC1
    Conserved Domains (3) summary
    cd10408
    Location:216 → 312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:44 → 98
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129 → 185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
Nucleotide Protein
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