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INPPL1 inositol polyphosphate phosphatase like 1 [ Canis lupus familiaris (dog) ]

Gene ID: 485209, updated on 5-Mar-2024

Summary

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Official Symbol
INPPL1provided by VGNC
Official Full Name
inositol polyphosphate phosphatase like 1provided by VGNC
Primary source
VGNC:VGNC:42037
See related
Ensembl:ENSCAFG00845010236
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (26108942..26122997, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (25670004..25684057, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (26018164..26032213, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (25900410..25914476, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (26116609..26130663, complement)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene ClpB family mitochondrial disaggregase Neighboring gene 60S ribosomal protein L35a-like Neighboring gene uncharacterized LOC119864984 Neighboring gene paired like homeobox 2A Neighboring gene folate receptor beta Neighboring gene folate receptor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein. Awad A, et al. Mol Biol Cell, 2013 Jul. PMID 23699395, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SHIP2 regulates epithelial cell polarity through its lipid product, phosphatidylinositol 4,5-Biphosphate, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein.
    Title: SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    26108942..26122997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038430227.1 → XP_038286155.1  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    UniProtKB/Swiss-Prot
    A0A8C0MWD2, A0A8I3NFE2
    UniProtKB/TrEMBL
    A0A8C0QVD3
    Related
    ENSCAFP00845014045.1, ENSCAFT00845018029.1
    Conserved Domains (5) summary
    cd09491
    Location:1201 → 1262
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:430 → 733
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:22 → 124
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    PHA03247
    Location:905 → 1209
    PHA03247; large tegument protein UL36; Provisional
    PRK01973
    Location:98 → 186
    PRK01973; septum site-determining protein MinC

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    25900410..25914476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038505582.1 → XP_038361510.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    Conserved Domains (5) summary
    cd09491
    Location:1201 → 1262
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:430 → 733
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:22 → 124
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    PHA03247
    Location:905 → 1209
    PHA03247; large tegument protein UL36; Provisional
    PRK01973
    Location:98 → 186
    PRK01973; septum site-determining protein MinC

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    26116609..26130663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038632935.1 → XP_038488863.1  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    Conserved Domains (5) summary
    cd09491
    Location:1201 → 1262
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:430 → 733
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:22 → 124
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    PHA03247
    Location:905 → 1209
    PHA03247; large tegument protein UL36; Provisional
    PRK01973
    Location:98 → 186
    PRK01973; septum site-determining protein MinC

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    26018164..26032213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038568762.1 → XP_038424690.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    UniProtKB/Swiss-Prot
    A0A8C0MWD2, A0A8I3NFE2
    UniProtKB/TrEMBL
    A0A8C0QVD3
    Conserved Domains (5) summary
    cd09491
    Location:1201 → 1262
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:430 → 733
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:22 → 124
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    PHA03247
    Location:905 → 1209
    PHA03247; large tegument protein UL36; Provisional
    PRK01973
    Location:98 → 186
    PRK01973; septum site-determining protein MinC

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25670004..25684057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_542327.7 → XP_542327.3  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    UniProtKB/Swiss-Prot
    A0A8C0MWD2, A0A8I3NFE2
    UniProtKB/TrEMBL
    A0A8C0QVD3
    Conserved Domains (5) summary
    cd09491
    Location:1201 → 1262
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:430 → 733
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    cd10343
    Location:22 → 124
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    PHA03247
    Location:905 → 1209
    PHA03247; large tegument protein UL36; Provisional
    PRK01973
    Location:98 → 186
    PRK01973; septum site-determining protein MinC
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A8I3NFE2.1 GenPept UniProtKB/Swiss-Prot:A0A8I3NFE2

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